| Effect of aspirin and ibuprofen on GI permeability during exercise. | |
| | |
MedLine Citation:
|
PMID: 17436199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study was conducted to determine the effects of aspirin or ibuprofen on gastrointestinal permeability when combined with exercise. Eight runners completed three 60 min treadmill runs at 70 % VO(2max). For 24 hours prior to each run, subjects ingested aspirin (2 x 325 mg), ibuprofen (2 x 200 mg), or placebo capsules every 6 hours. Immediately before each run, a solution containing 5 g sucrose, 5 g lactulose, and 2 g rhamnose was ingested. Urine produced during each run, and for 4 h afterwards was collected. Urinary excretion of sucrose is an indicator of gastroduodenal permeability. The excretion ratio of lactulose-to-rhamnose assesses small intestinal permeability. Sucrose excretion (%) was greater (p < 0.017) for aspirin (0.37 [0.2 - 0.97]) compared to placebo (0.09 [0.05 - 0.30]) or ibuprofen (0.22 [0.1 - 0.39]) and sucrose excretion for ibuprofen was greater than placebo. The lactulose-to-rhamnose ratio was greater for aspirin (0.09 [0.08 - 0.30]) than placebo (0.065 [0.04 - 0.08]) however ibuprofen (0.08 [0.06 - 0.19]) was not different from aspirin or placebo. These results indicate that with prolonged running, gastroduodenal permeability is increased if aspirin or ibuprofen is used prior to such exercise. Furthermore, aspirin promotes greater gastroduodenal permeability and also increases small intestinal permeability. |
| | |
Authors:
|
G P Lambert; M Boylan; J-P Laventure; A Bull; S Lanspa |
Related Documents
:
|
21390469 - Torque, myoeletric sygnal and heart rate responses during concentric and eccentric exer... 18367839 - Melanoma markers in marathon runners: increase with sun exposure and physical strain. 18438219 - Changes in spring-mass model parameters and energy cost during track running to exhaust... 15615829 - Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proli... 15139159 - Effect of recovery modality on 4-hour repeated treadmill running performance and change... 2947039 - Prolonged exercise causes an increase in the activity of galactosylhydroxylysyl glucosy... 16600839 - An assessment of obese and non obese girls' metabolic rate during television viewing, r... 6421179 - Effect of bilateral vagotomy on the ventilatory responses of the water snake nerodia si... 20593329 - Construct validity of rt3 accelerometer: a comparison of level-ground and treadmill wal... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-13 |
Journal Detail:
|
Title: International journal of sports medicine Volume: 28 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-08-28 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
|
Languages: eng Pagination: 722-6 Citation Subset: IM |
Affiliation:
|
Department of Exercise Science and Athletic Training, Creighton University, Omaha, United States. plambert@creigton.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aspirin / pharmacology* Female Gastrointestinal Tract / drug effects* Humans Ibuprofen / pharmacology* Male Oxygen Consumption Permeability / drug effects* Prospective Studies Running / physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
|
15687-27-1/Ibuprofen; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes of bone turnover markers after marathon running over 245 km.
Next Document: Imbalanced nutrition of top-level swimmers.