| Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress. | |
| | |
MedLine Citation:
|
PMID: 21920059 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Using hyperbaric oxygen (HBO) therapy as an in vivo oxidation model, we investigated the effect of a diet enriched in ascorbic acid (AA) on HBO-induced oxidative stress. Volunteers (n 46) were allocated to the AA-rich diet group or the control group. Blood samples were collected at the basal time, after the 1-week diet before and immediately after the HBO treatment, and 1 week after the HBO treatment. AA level, total antioxidant status (TAS), hydroperoxides (HP), lymphocyte DNA oxidation and DNA repair capacity were assessed. The expression of genes involved in oxidative stress was evaluated in lymphocytes and the protein activity of the modulated genes was determined in the plasma. The AA level and the antioxidant status of plasma were increased by AA-rich food consumption. HBO exposure did not affect the AA levels or TAS, but induced HP formation in the control group. The lymphocytes isolated from dietary-supplemented subjects were resistant to ex vivo DNA oxidation, showing an increased DNA repair capacity compared with controls. A difference in gene expression pattern was observed between the groups. AA-rich foods provide dual protection against oxidative stress, enhancing plasma antioxidant levels and stimulating genes involved in cell detoxification. |
| | |
Authors:
|
Renata Alleva; Ferruccio Di Donato; Elisabetta Strafella; Sara Staffolani; Linda Nocchi; Battista Borghi; Elettra Pignotti; Lory Santarelli; Marco Tomasetti |
Related Documents
:
|
12846739 - Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chro... 16243509 - Prolonged increase in dietary phosphate intake alters bone mineralization in adult male... 8559729 - A method to determine and factors that influence in vivo solubilization of phosphates i... 940279 - Skeletal resistance to the calcemic action of parathyroid hormone in uremia: role of 1,... 15758109 - Influence of phytase on water-soluble phosphorus in poultry and swine manure. 20163639 - Water-soluble phosphorus excretion in pigs fed diets supplemented with microbial phytase. 2015959 - Effects of dietary fat and adipose tissue location on insulin action in young boar adip... 19479079 - Zidovudine/lamivudine for hiv-1 infection contributes to limb fat loss. 3762319 - A high cholesterol/cholate diet induced fatty liver in spontaneously hypertensive rats. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-16 |
Journal Detail:
|
Title: The British journal of nutrition Volume: - ISSN: 1475-2662 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: 1-10 Citation Subset: - |
Affiliation:
|
Department of Anesthesiology Research Unit, IRCCS Rizzoli Orthopaedic Institute, Via Pupilli, 1-40136 Bologna, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Percutaneous upsizing of a Blalock-Taussig shunt.
Next Document: n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in ...