Document Detail

Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study.
MedLine Citation:
PMID:  15675894     Owner:  NLM     Status:  MEDLINE    
Manifestations of vascular disease, including microvascular changes, constitute the major part of the morbidity and mortality in diabetic patients. Oxidative stress has been suggested to play an important role in the vascular dysfunction of diabetic patients. Furthermore, epidemiological observations indicate a beneficial effect of an increased dietary intake of antioxidants. The present study tested the hypothesis that the antioxidant ascorbic acid influences microcirculatory function in patients with Type II diabetes. Patients with Type II diabetes were treated with 1 g of ascorbic acid three times a day for 2 weeks in a randomized placebo-controlled double-blind cross-over design. Microvascular reactivity was assessed by vital capillaroscopy and PRH (post-occlusive reactive hyperaemia). hs-CRP (high-sensitivity C-reactive protein), IL-6 (interleukin-6), IL-1ra (interleukin-1 receptor antagonist) and ox-LDL (oxidized low-density lipoprotein) were analysed. The results showed no significant change in microvascular reactivity assessed after 2 weeks of ascorbic acid treatment. TtP (time to peak) was 12.0+/-3.3 s before and 11.2+/-3.5 s after ascorbic acid (n=17). In comparison, TtP was 11.5+/-2.9 s before and 10.6+/-2.8 s after placebo (not significant). IL-1ra, IL-6, hs-CRP and ox-LDL did not change significantly after ascorbic acid, neither as absolute or relative values. In conclusion, in contrast with some studies reported previously, we could not demonstrate an effect of continuous oral treatment with ascorbic acid on microvascular reactivity assessed at the level of individual capillaries. Furthermore, we found no indication of an effect on inflammatory cytokines or ox-LDL.
Qing Lu; Ingemar Björkhem; Bengt Wretlind; Ulf Diczfalusy; Peter Henriksson; Anna Freyschuss
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  108     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-17     Completed Date:  2005-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  507-13     Citation Subset:  IM    
Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm SE-141 86, Sweden.
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MeSH Terms
Antioxidants / therapeutic use*
Ascorbic Acid / therapeutic use*
C-Reactive Protein / analysis
Cross-Over Studies
Diabetes Mellitus, Type 2 / blood,  drug therapy*
Double-Blind Method
Endothelium, Vascular / drug effects
Interleukin-6 / blood
Lipoproteins, LDL / blood
Middle Aged
Receptors, Interleukin-1 / blood
Treatment Failure
Reg. No./Substance:
0/Antioxidants; 0/Interleukin-6; 0/Lipoproteins, LDL; 0/Receptors, Interleukin-1; 0/oxidized low density lipoprotein; 50-81-7/Ascorbic Acid; 9007-41-4/C-Reactive Protein

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