| Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents. | |
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MedLine Citation:
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PMID: 20122981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ascorbic acid is a sugar acid and an essential vital food nutrient found mainly in fruits and vegetables. The purpose of this study was to investigate the effects of ascorbic acid against arsenic induced oxidative stress in blood of rat. In rat, treatment with ascorbic acid prevented the increased serum enzymatic activity of AST, ALT, ALP, ACP and LDH. In addition, treatment with ascorbic acid prevented elevated production of LPO, PC and NO and restored the depletion of reduced SOD and CAT activities. Interestingly, ascorbic acid markedly upregulated lymphocytes relative mRNA expression of lymphocytes SOD2 gene corresponding to GAPDH, house keeping candidate gene in arsenic-treated rat, which might provide anti-oxidative activity in the blood. |
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Authors:
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Tanmoy Rana; Asit Kumar Bera; Subhashree Das; Diganta Pan; Subhasish Bandyopadhyay; Debasis Bhattacharya; Sumanta De; Sourav Sikdar; Subrata Kumar Das |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-01 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1072-7 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Indian Veterinary Research Institute, Eastern Regional Station, 37, Belgachia Road, Kolkata 700 037, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Arsenic Poisoning / metabolism, prevention & control* Ascorbic Acid / pharmacology* Biological Markers / blood Catalase / metabolism Chronic Disease Disease Models, Animal Enzymes / blood Gene Expression Regulation, Enzymologic / drug effects Glyceraldehyde-3-Phosphate Dehydrogenases / genetics, metabolism Lipid Peroxidation / drug effects Lymphocytes / chemistry, drug effects Male Nitric Oxide / metabolism Oxidative Stress / drug effects* RNA, Messenger / metabolism Rats Rats, Wistar Superoxide Dismutase / genetics, metabolism Up-Regulation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Enzymes; 0/RNA, Messenger; 10102-43-9/Nitric Oxide; 50-81-7/Ascorbic Acid; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase; EC 1.15.1.1/superoxide dismutase 2; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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