Document Detail

Effect of ascorbate on acrolein modification of very low density lipoprotein and uptake of oxidized apolipoprotein e by hepatocytes.
MedLine Citation:
PMID:  16195596     Owner:  NLM     Status:  MEDLINE    
Acrolein modification of apolipoprotein (apo) E in human very low density lipoprotein (VLDL) was suppressed by ascorbate. Acrolein-modified apoE in VLDL was not taken up by human hepatoma cell whereas unmodified apoE in the presence of ascorbate was taken up. These results suggest that ascorbate can play an important role in maintaining proper lipoprotein metabolism by the antioxidant effect.
Hirofumi Arai; Koji Uchida; Kazuyuki Nakamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  69     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-30     Completed Date:  2006-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1760-2     Citation Subset:  IM    
Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube 755-8505, Japan.
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MeSH Terms
Acrolein / chemistry,  metabolism*
Antioxidants / pharmacology
Apolipoproteins E / metabolism*
Ascorbic Acid / pharmacology*
Hepatocytes / drug effects,  metabolism*
Lipoproteins, VLDL / metabolism*
Reg. No./Substance:
0/Antioxidants; 0/Apolipoproteins E; 0/Lipoproteins, VLDL; 107-02-8/Acrolein; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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