Document Detail

Effect of ischemia/reperfusion as a systemic phenomenon on anastomotic healing in the left colon.
MedLine Citation:
PMID:  10865046     Owner:  NLM     Status:  MEDLINE    
Intestinal ischemia/reperfusion provokes a local inflammatory response leading to a systemic inflammatory state. In this study we aimed to assess the effects of intestinal ischemia/reperfusion injury on anastomotic healing in the left colon with an intact vascular supply. A total of 94 Wistar albino rats were divided into three groups: sham-operated control (group I, n = 25), 30 minutes of intestinal ischemia/reperfusion (group II, n = 40), and 7-day allopurinol pretreatment and intestinal ischemia/reperfusion (group III, n = 29). After the reperfusion experiment, a segmental left colon resection and anastomosis were done. On postoperative days 3 and 7 anastomotic bursting pressure, anastomotic and operative complications, and intraabdominal adhesions were assessed. Mortality rates were 1/25, 16/40, and 4/29 for groups I, II, and III, respectively (p = 0.001). There was no difference among the groups for wound and anastomotic healing parameters evaluated by macroscopic criteria. On postoperative day 7 the mean bursting pressures were 220.3 +/- 18.5, 162.0 +/- 21.0, and 213.9 +/- 24.7 for groups I, II, and II, respectively (p = 0.000). Significantly dense adhesions were found in group II (p = 0.000). Allopurinol pretreatment prevented the effects of ischemia/reperfusion on anastomotic healing of the left colon. Intestinal/ischemia reperfusion causes impairment of anastomotic healing of the left colon. In addition to remote organ effects, reperfusion injury may affect anastomotic healing in the viscera with an intact vascular supply.
M A Kuzu; A Tanik; I T Kale; A K Aşlar; C Köksoy; C Terzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of surgery     Volume:  24     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-06     Completed Date:  2000-09-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  990-4     Citation Subset:  IM    
Department of Surgery, Faculty of Medicine, University of Ankara, Sihhiye, 06100 Ankara, Turkey.
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MeSH Terms
Allopurinol / therapeutic use
Anastomosis, Surgical*
Colon / blood supply,  physiopathology,  surgery*
Colonic Diseases / etiology*,  physiopathology,  prevention & control
Free Radical Scavengers / therapeutic use
Postoperative Complications*
Rats, Wistar
Reperfusion Injury / complications*,  physiopathology
Tissue Adhesions
Wound Healing*
Reg. No./Substance:
0/Free Radical Scavengers; 315-30-0/Allopurinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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