Document Detail

Effect of artificial valves on intestinal adaptation in the short-bowel syndrome: an integrated study of morphological and functional changes in rats.
MedLine Citation:
PMID:  10810217     Owner:  NLM     Status:  MEDLINE    
Two-third-resections of the proximal or distal small bowel with and without artificial valves were performed in rats. Intestinal adaptation led to a significant increase in bowel diameter, villus height and villus diameter and consequently in absorptive mucosal surface area per unit of serosal area. Additional artificial valve construction did not affect the calculated mucosal surface area after proximal resection, while it significantly decreased the absorptive area by the occurrence of large, plump villi after distal resection. There was no change in small-intestinal absorption of water, glucose and electrolytes per unit mucosa with valve construction. DNA cytometry showed that artificial valves led to mucosal hyperplasia without hypertrophy. These morphological changes coincided with a significant increase in basal and stimulated gastrin release. The body weight was unchanged or even worse in the valve groups than after resection alone, despite a significantly prolonged transit time. Therefore, in our study, artificial valves did not result in functional improvements after small intestinal resections.
S Willis; B Klosterhalfen; S Titkova; M Anurov; M Polivoda; M Max; A P Ottinger; V Schumpelick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  32     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  2000  
Date Detail:
Created Date:  2000-07-25     Completed Date:  2000-07-25     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  111-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Department of Surgery, Technical University Aachen, Germany.
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MeSH Terms
Adaptation, Physiological*
Gastrins / metabolism
Intestinal Absorption
Intestine, Small / metabolism,  pathology,  physiopathology*,  surgery*
Prostheses and Implants*
Rats, Sprague-Dawley
Short Bowel Syndrome / metabolism,  pathology,  physiopathology*,  surgery*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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