Document Detail

Effect of arterial hypertension on chronic urticaria duration.
MedLine Citation:
PMID:  19927539     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reliable clinical or laboratory markers of chronic idiopathic urticaria (CIU) duration are not available. Angioedema, autologous serum skin test (ASST) results, and antithyroid antibodies have been inconsistently associated with longer urticaria duration. OBJECTIVE: To investigate the association of clinical and laboratory parameters with CIU duration, including systemic hypertension, because activation of the coagulation cascade pathway may contribute to the pathogenesis of CIU. METHODS: We performed a prospective study of a cohort of 228 consecutive adult patients with CIU of moderate to severe intensity referred to 2 outpatient allergy clinics and followed up for a 3- to 5-year period. The association of clinical and laboratory parameters (sex, atopy, markers of autoimmunity, antithyroid antibodies, positive ASST result, Helicobacter pylori infection, and hypertension) with urticaria duration was analyzed using semiparametric multivariable proportional hazards models (Cox regression) using remission as main outcome measure. RESULTS: Apart from systemic hypertension (hazard ratio, 0.71; 95% confidence interval, 0.53-0.95; P = .02), none of the considered parameters influenced CIU remission of our patients; 74% and 54% of our patients with and without hypertension, respectively, still had CIU after 5 years. CONCLUSIONS: Our results show, for the first time to our knowledge, that hypertension is associated with extended duration of CIU. This observation, together with the previous findings that point to vascular and coagulation involvement in CIU, may suggest a new approach to antihistamine-refractory CIU treatment, including adequate treatment of hypertension.
Franco Nebiolo; Roberta Bergia; Luisa Bommarito; Massimiliano Bugiani; Enrico Heffler; Aurelia Carosso; Gloria Castiglioni; Giuseppe Guida; Iuliana Badiu; Stefano Pizzimenti; Sabrina Mietta; Nicoletta Ferrero; Giovanni Rolla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  103     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  407-10     Citation Subset:  IM    
Allergy and Clinical Immunology, University of Torino and AO Ordine Mauriziano Hospital, Torino, Italy.
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MeSH Terms
Aged, 80 and over
Chronic Disease
Cohort Studies
Disease Progression
Follow-Up Studies
Histamine Antagonists / therapeutic use
Hypertension / complications*,  drug therapy
Middle Aged
Proportional Hazards Models
Treatment Outcome
Urticaria / complications*,  drug therapy,  physiopathology*
Reg. No./Substance:
0/Histamine Antagonists

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