Document Detail


Effect of aromatic acids on the influx of aromatic amino acids in rat brain slices.
MedLine Citation:
PMID:  598439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influx of [3H]phenylalanine, [3H]tyrosine and [3H]tryptophan into brain cells was studied using brain slices from adult rats. Each aromatic amino acid inhibited the influx of the others into the brain cells. Tryptophan inhibited non-competitively the influx of phenylalanine, and phenylalanine similarly that of tyrosine and tryptophan. On the other hand, tyrosine inhibited competitively the influx of phenylalanine, and similarly tryptophan that of tyrosine, and tyrosine that of tryptophan. Among the aromatic organic acids tested, only phenylpyruvate and homogentisate had any inhibitory effect on the influx of the aromatic amino acids. These effects were generally competitive, non-competitive inhibition being obtained only in the inhibition of phenylalanine influx by homogentisate. The existence of only one common transport system for aromatic amino acids appear to be unlikely.
Authors:
P Lähdesmäki; M L Hannus
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Experimental brain research     Volume:  30     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-03-29     Completed Date:  1978-03-29     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  539-48     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects,  metabolism*
Dose-Response Relationship, Drug
Homogentisic Acid / pharmacology
Kinetics
Phenylalanine / metabolism*,  pharmacology
Phenylpyruvic Acids / pharmacology
Rats
Tryptophan / metabolism*,  pharmacology
Tyrosine / metabolism*,  pharmacology
Chemical
Reg. No./Substance:
0/Phenylpyruvic Acids; 42HK56048U/Tyrosine; 47E5O17Y3R/Phenylalanine; 8DUH1N11BX/Tryptophan; NP8UE6VF08/Homogentisic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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