| Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients. | |
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MedLine Citation:
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PMID: 20616774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether or not the use of an arginine-containing nutritional supplement could result in significantly shorter pressure ulcer (PU) healing times in people with spinal cord injuries living in the community, compared with a comparative historical control group. METHOD: Eighteen spinal-cord-injured patients (all part of a hospital spinal outreach service) received 9 g of a commercial powdered arginine supplement per day until full PU healing occurred. Healing rates were compared against 17 historical control patients (as assessed by medical history audit). RESULTS: Baseline characteristics (age, gender, injury level and time) were similar between groups. Mean ulcer healing times were 10.5 +/- 1.3 weeks versus 21 +/- 3.7 weeks (p<0.05) in the intervention and control groups respectively. Comparison of healing rates in the intervention group against expected healing rates derived from the medical literature showed that intervention patients had a significantly shorter mean healing time (category 2 PU: 5.5+/-1.3 weeks versus 13.4 weeks; category 3 PU: 12.5 +/- 1.9 weeks versus 18.2 weeks; category 4 PU: 14.4 +/- 4.8 weeks versus 22.1 weeks). A diagnosis of diabetes did not significantly alter healing rates in either group. CONCLUSION: Results from this observational study show a promising benefit of arginine supplementation on PU healing for individuals with spinal cord injury living in the community. |
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Authors:
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S Brewer; K Desneves; L Pearce; K Mills; L Dunn; D Brown; T Crowe |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of wound care Volume: 19 ISSN: 0969-0700 ISO Abbreviation: J Wound Care Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9417080 Medline TA: J Wound Care Country: England |
Other Details:
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Languages: eng Pagination: 311-6 Citation Subset: N |
Affiliation:
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School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Arginine / pharmacology, therapeutic use* Dietary Supplements* / standards Female Humans Male Middle Aged Nutrition Assessment Nutritional Status Pressure Ulcer / diagnosis, diet therapy*, etiology Prospective Studies Risk Factors Severity of Illness Index Spinal Cord Injuries / complications* Time Factors Treatment Outcome Victoria Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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