Document Detail

Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients.
MedLine Citation:
PMID:  20616774     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether or not the use of an arginine-containing nutritional supplement could result in significantly shorter pressure ulcer (PU) healing times in people with spinal cord injuries living in the community, compared with a comparative historical control group. METHOD: Eighteen spinal-cord-injured patients (all part of a hospital spinal outreach service) received 9 g of a commercial powdered arginine supplement per day until full PU healing occurred. Healing rates were compared against 17 historical control patients (as assessed by medical history audit). RESULTS: Baseline characteristics (age, gender, injury level and time) were similar between groups. Mean ulcer healing times were 10.5 +/- 1.3 weeks versus 21 +/- 3.7 weeks (p<0.05) in the intervention and control groups respectively. Comparison of healing rates in the intervention group against expected healing rates derived from the medical literature showed that intervention patients had a significantly shorter mean healing time (category 2 PU: 5.5+/-1.3 weeks versus 13.4 weeks; category 3 PU: 12.5 +/- 1.9 weeks versus 18.2 weeks; category 4 PU: 14.4 +/- 4.8 weeks versus 22.1 weeks). A diagnosis of diabetes did not significantly alter healing rates in either group. CONCLUSION: Results from this observational study show a promising benefit of arginine supplementation on PU healing for individuals with spinal cord injury living in the community.
S Brewer; K Desneves; L Pearce; K Mills; L Dunn; D Brown; T Crowe
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of wound care     Volume:  19     ISSN:  0969-0700     ISO Abbreviation:  J Wound Care     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417080     Medline TA:  J Wound Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-6     Citation Subset:  N    
School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia.
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MeSH Terms
Administration, Oral
Arginine / pharmacology,  therapeutic use*
Dietary Supplements* / standards
Middle Aged
Nutrition Assessment
Nutritional Status
Pressure Ulcer / diagnosis,  diet therapy*,  etiology
Prospective Studies
Risk Factors
Severity of Illness Index
Spinal Cord Injuries / complications*
Time Factors
Treatment Outcome
Wound Healing / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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