| Effect of arachidonic acid on twitch tension of the rat phrenic nerve-diaphragm. | |
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MedLine Citation:
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PMID: 8450467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have demonstrated that unsaturated fatty acids are involved in the regulation of neuroeffector function. I have extended these studies by examining the effect of arachidonic acid on neuromuscular function in vitro using the rat phrenic nerve-diaphragm preparation. Arachidonic acid caused a time-and dose-dependent reduction in indirectly stimulated twitch tension, but had no effect on directly stimulated twitch tension. Linoleic acid and linolenic acid also reduced indirectly stimulated twitch tension, whereas stearic acid, oleic acid and arachidic acid had no effect. None of three blockers of arachidonic acid metabolism, the cyclooxygenase inhibitor indomethacin, the lipoxygenase inhibitor nordihydroguaiaretic acid or the cytochrome P-450 inhibitor ketoconazole, altered the effect of arachidonic acid on twitch tension. The free radical scavenger superoxide dismutase eliminated the inhibitory effect of arachidonic acid on twitch tension, suggesting that superoxide anion played a role in arachidonic acid's action. |
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Authors:
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R D Crosland |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 264 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-04-14 Completed Date: 1993-04-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1311-4 Citation Subset: IM |
Affiliation:
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Toxinology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / pharmacology* Fatty Acids / pharmacology Indomethacin / pharmacology Male Neuromuscular Junction / drug effects*, physiology Rats Rats, Sprague-Dawley Superoxide Dismutase / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 506-32-1/Arachidonic Acid; 53-86-1/Indomethacin; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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