Document Detail

Effect of aqueous extracts of Ecballium elaterium rich, in the rabbit model of rhinosinusitis.
MedLine Citation:
PMID:  16191438     Owner:  NLM     Status:  MEDLINE    
This study was designated to investigate anti-inflammatory effect of aqueous extract of Ecballium elaterium, which is topically applied for treatment of rhinosinusitis as a traditional folk medicine in Turkey. Therapeutic potential of E. elaterium as an anti-inflammatory agent was examined by measurement of NO* metabolites in a rabbit model of rhinosinusitis. The results showed that both activity of NOS enzyme and concentration of NO* metabolites were significantly reduced by topical administration of E. elaterium extract in therapy group as compared to the control. Thus, the data suggest E. elaterium extract may have the potential to be used as anti-inflammation agent, and can be used in the treatment of rhinosinusitis diseases.
Celil Uslu; R Murat Karasen; Fikrettin Sahin; Seyithan Taysi; Fatih Akcay
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2005-09-26
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  70     ISSN:  0165-5876     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  515-8     Citation Subset:  IM    
Department of Otolaryngology, Haydarpasa State Hospital for Research and Education, Uskudar, Istanbul, Turkey.
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MeSH Terms
Administration, Topical
Anti-Infective Agents / therapeutic use*
Nitric Oxide / metabolism
Sinusitis / metabolism,  microbiology,  therapy*
Staphylococcal Infections / complications
Staphylococcus aureus
Reg. No./Substance:
0/Anti-Infective Agents; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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