| Effect of apolipoproteins on the induction of hepatic steatosis in rats. | |
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MedLine Citation:
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PMID: 7450399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incorporation of apolipoprotein E isolated from human very low density lipoproteins on a triglyceride emulsion produced a substantial increment in hepatic triglyceride after 1 h of in vitro perfusion through the isolated liver of a fasted rat. Both gross and microscopic morphology confirmed a substantial steatosis. Perfusions with triglyceride emulsions which contained no apoipoproteins resulted in a modest increment in hepatic triglyceride although considerably less than emulsions with the E protein, and no morphologic features of steatosis. The steatosis induced in the in vitro perfused fasted livers by the emulsions with E protein could be prevented when CIII-1 apoprotein was also incorporated on the emulsion. A fed rat liver perfused with the E-enriched emulsion accumulated significantly less triglyceride than the fasted preparation. These data suggest that the apoprotein patterns of the plasma triglyceride-rich lipoproteins are of considerable importance for the partition of triglyceride between liver and plasma. |
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Authors:
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S H Quarfordt; F A Shelburne; W Meyers; L Jakoi; J Hanks |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 80 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1981 Jan |
Date Detail:
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Created Date: 1981-03-24 Completed Date: 1981-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 149-53 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoprotein C-III Apolipoproteins / adverse effects, metabolism*, pharmacology Apolipoproteins C* Apolipoproteins E Fasting Fatty Liver / chemically induced*, pathology Liver / metabolism*, pathology Male Perfusion Rats Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein C-III; 0/Apolipoproteins; 0/Apolipoproteins C; 0/Apolipoproteins E; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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