Document Detail


Effect of apolipoprotein E polymorphism on the serum lipid response to a hypolipidemic diet rich in monounsaturated fatty acids in patients with hypercholesterolemia and combined hyperlipidemia.
MedLine Citation:
PMID:  7825526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effect of variation at the apolipoprotein (apo) E gene locus on the serum lipid response to a hypolipidemic diet rich in monounsaturated fatty acids (MUFA). Lipoprotein changes were assessed in 122 outpatients with type IIa (n = 70) and type IIb (n = 52) hyperlipidemia [80 men and 42 women with apo E phenotypes 3/2 (n = 27), 3/3 (n = 48), and 4/3 (n = 47)] who were switched from their basal diet containing 40% fat (22% MUFA) to an isoenergetic diet containing 31% fat (MUFA content similar to that of the basal diet) for 12 wk. Significant (P < 0.005) reductions of total, LDL, and VLDL cholesterol; triglycerides; and apo B occurred in subjects regardless of WHO phenotype. Triglycerides and VLDL cholesterol decreased more in type IIb than in type IIa subjects: 25% vs 12% and 21% vs 15%, respectively (P = 0.01). HDL cholesterol tended to decrease only in women. The heterogeneity of lipoprotein responses to dietary intervention was unrelated to apo E phenotypes. In these hyperlipidemic subjects, however, diet-induced favorable changes in serum lipoproteins were selectively influenced by WHO phenotype.
Authors:
D Zambón; E Ros; E Casals; C Sanllehy; A Bertomeu; I Campero
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  61     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-13     Completed Date:  1995-02-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-8     Citation Subset:  AIM; IM    
Affiliation:
Lipid Clinic (Gastroenterology Service), Hospital Clínic i Provincial, University of Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoproteins E / genetics*
Diet Records
Dietary Fats, Unsaturated / pharmacology*
Energy Intake
Fatty Acids, Monounsaturated / therapeutic use*
Female
Humans
Hypercholesterolemia / blood,  diet therapy,  genetics*
Hyperlipidemias / blood,  diet therapy,  genetics*
Lipids / blood*
Male
Middle Aged
Patient Compliance
Phenotype
Polymorphism, Genetic
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Monounsaturated; 0/Lipids

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