Document Detail


Effect of antiretroviral drugs on maternal CD4 lymphocyte counts, HIV-1 RNA levels, and anthropometric parameters of their neonates.
MedLine Citation:
PMID:  15962081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To study the effect of antiretroviral drugs administered during pregnancy on CD4 lymphocyte counts and HIV-1 RNA levels of pregnant women and on the anthropometric parameters of their neonates. METHODS: A prospective study was conducted on 57 pregnant women and their neonates divided into 3 groups: ZDV Group, HIV-infected mothers taking zidovudine (n=20); triple therapy (TT) Group, mothers taking zidovudine+lamivudine+nelfinavir (n=25), and Control Group, normal women (n=12). CD4 lymphocyte counts and HIV-1 RNA levels of pregnant women were analyzed during two periods of pregnancy. The perinatal prognosis took into account preterm rates, birth weight, intrauterine growth restriction, perinatal death, and vertical transmission of HIV-1. Data were analyzed statistically using the nonparametric chi-square, Mann-Whitney, Friedman, Kruskal-Wallis, and Wilcoxon matched pairs tests, with the level of significance set at P<.05. RESULTS: The major maternal demographic and anthropometric data were homogeneous for the various groups. HIV-1 viral burden, which was initially elevated, median of 14,370 copies/mL, was significantly reduced in the TT group, reaching 40 copies/mL. With respect to T-CD4+ lymphocyte counts, there was a significant recovery in Group TT at the end of pregnancy, this value being significantly different from that for the ZDV group (P=0052). There was no difference between groups regarding gestation length, Apgar scores, or neonatal anthropometric classification. There was no case of vertical HIV-1 transmission. CONCLUSIONS: The results obtained for the present series demonstrate the efficiency and suggest safety of the use of antiretroviral drugs during pregnancy as revealed by anthropometric parameters of the neonate.
Authors:
Patrícia El Beitune; Geraldo Duarte; Alcyone Artioli Machado; Silvana Maria Quintana; Ernesto A Figueiró-Filho; Renata Abduch
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-13
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  60     ISSN:  1807-5932     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-17     Completed Date:  2005-12-22     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Medicine School of Ribeirão Preto, University of São Paulo, Brazil. pbeitune@ig.com.br
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-HIV Agents / therapeutic use*
Birth Weight / drug effects*
CD4 Lymphocyte Count
Case-Control Studies
Female
Fetal Development / drug effects*
HIV Infections / drug therapy*,  transmission
HIV-1 / genetics
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control
Lamivudine / therapeutic use
Nelfinavir / therapeutic use
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Prospective Studies
RNA, Viral / analysis
Zidovudine / therapeutic use
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/RNA, Viral; 134678-17-4/Lamivudine; 159989-64-7/Nelfinavir; 30516-87-1/Zidovudine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Edema and malignancy in meningiomas.
Next Document:  Study of warm ischemia followed by reperfusion on a lower limb model in rats: effect of allopurinol ...