Document Detail

Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal.
MedLine Citation:
PMID:  9388088     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Much has been written about the potential role of antioxidants in the prevention of atherosclerosis.
OBJECTIVE: To assess the short-term effect of a single high-fat meal with and without pretreatment with antioxidant vitamins on endothelial function in healthy, normocholesterolemic subjects.
DESIGN: Observer-blinded randomized trial.
SETTING: University hospital.
PARTICIPANTS: Twenty healthy, normocholesterolemic (total and low-density lipoprotein cholesterol <5.2 mmol/L and <3.4 mmol/L [<200 mg/dL and <130 mg/ dL], respectively), male (7) and female (13) hospital employee volunteers, aged 24 to 54 years.
INTERVENTION: Three randomly administered breakfasts: (1) a high-fat meal (3766 J [900 calories], 50 g of fat); (2) a low-fat meal (3766 J [900 calories], 0 g of fat); and (3) a high-fat meal and pretreatment with oral administration of vitamins C (1 g) and E (800 IU) (high-fat meal with vitamins). A subgroup of 10 subjects also ate the low-fat meal with the same vitamin pretreatment (low-fat meal with vitamins).
MAIN OUTCOME MEASURE: High-resolution ultrasound assessed flow-mediated (endothelium-dependent) brachial artery vasodilation measured as percent diameter change before and hourly for 6 hours following each meal.
RESULTS: Flow-mediated vasodilation fell from a mean+/-SD of 20%+/-8% before to 12%+/-6%, 10%+/-6%, and 8%+/-9% at 2, 3, and 4 hours, respectively, after the high-fat meal (P<.001). No significant changes in flow-mediated vasodilation occurred after the low-fat meal, high-fat meal with vitamins, or low-fat meal with vitamins. The change in flow-mediated vasodilation after the low-fat and high-fat meals correlated inversely with the 2-hour postprandial change in triglyceride levels (r=-0.54; P<.001).
CONCLUSION: A single high-fat meal transiently reduces endothelial function for up to 4 hours in healthy, normocholesterolemic subjects, probably through the accumulation of triglyceride-rich lipoproteins. This decrease is blocked by pretreatment with antioxidant vitamins C and E, suggesting an oxidative mechanism.
G D Plotnick; M C Corretti; R A Vogel
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  JAMA     Volume:  278     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-10     Completed Date:  1997-12-10     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1682-6     Citation Subset:  AIM; IM    
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MeSH Terms
Antioxidants / administration & dosage,  pharmacology*
Ascorbic Acid / administration & dosage,  pharmacology*
Blood Flow Velocity / drug effects
Blood Glucose / metabolism
Blood Pressure
Brachial Artery / drug effects,  ultrasonography
Dietary Fats / administration & dosage,  pharmacology*
Endothelium, Vascular / drug effects*,  ultrasonography
Heart Rate
Lipoproteins / blood
Middle Aged
Oxidative Stress
Vasodilation / drug effects*
Vitamin E / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Antioxidants; 0/Blood Glucose; 0/Dietary Fats; 0/Lipoproteins; 1406-18-4/Vitamin E; PQ6CK8PD0R/Ascorbic Acid
Comment In:
JAMA. 1998 Apr 8;279(14):1069-70   [PMID:  9546563 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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