Document Detail


Effect of antioxidant therapy on hospital stay and complications in patients with early acute pancreatitis: a randomised controlled trial.
MedLine Citation:
PMID:  20426279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxidative stress (OS) in acute pancreatitis (AP) has been pathologically linked with the systemic inflammatory response and antioxidant supplementation may have a clinical benefit. METHODS: In this prospective, randomised open label, controlled pilot study, patients admitted within 72 hours of onset of pain were randomised to receive either placebo (only standard medical treatment; SMT) or antioxidants (vitamin C 500 mg, N-acetyl cysteine 200 mg 8 hourly and antoxyl forte 1 capsule hourly with standard medical treatment; SMT + AO) daily, following informed consent. Patients with co-morbid illness and pregnancy were excluded. Primary efficacy measures were length of hospital stay and complications whilst secondary measures were biochemical markers of oxidative stress (thiobarbituric acid reactive substances [TBARS] and superoxide dismutase [SOD] and total antioxidant capacity [TAC] and vitamin C) at Days 1, 3 and 7. RESULTS: Of 53 patients, 30 patients were randomised to SMT and 23 patients to SMT + AO. The mean duration of hospital stay in the SMT group (10.3 +/- 7 days) was more compared to SMT + AOT (7.2 +/- 5 days), but was not statistically significant (p=0.07), complications were similar in the 2 groups. At Day 7, OS was significantly lower in the SMT + AO group when compared with the SMT group (TBARS, p=0.05; SOD, p=0.03) with a significant increase in FRAP and vitamin C (p=0.01). CONCLUSIONS: Antioxidant supplementation may decrease the length of hospital stay and complication rate in patients with AP, but a larger clinical trial is needed to support this hypothesis. Further, it decreased the OS and improved the antioxidant status in patients with AP.
Authors:
Javvaji Sateesh; Payal Bhardwaj; Namrata Singh; Anoop Saraya
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Tropical gastroenterology : official journal of the Digestive Diseases Foundation     Volume:  30     ISSN:  0250-636X     ISO Abbreviation:  Trop Gastroenterol     Publication Date:    2009 Oct-Dec
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8107122     Medline TA:  Trop Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi-110029, India.
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / therapeutic use*
Acute Disease
Adult
Antioxidants / therapeutic use*
Ascorbic Acid / therapeutic use*
Biological Markers / blood
Female
Humans
Length of Stay / statistics & numerical data
Male
Oxidative Stress
Pancreatitis / complications,  drug therapy*
Pilot Projects
Placebos
Prospective Studies
Statistics, Nonparametric
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Placebos; 50-81-7/Ascorbic Acid; 616-91-1/Acetylcysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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