Document Detail

Effect of an antioxidant functional food beverage on exercise-induced oxidative stress: a long-term and large-scale clinical intervention study.
MedLine Citation:
PMID:  19857542     Owner:  NLM     Status:  MEDLINE    
The efficacy of long-term intake of a novel functional food supplement Funciona™ containing vitamins and juiced fruits was evaluated in order to assess the net effect of physical activity and antioxidant potentials in healthy older adult population. The long-term (2 years) and large-scale (400 older adult subjects) interventional study was based on both moderate-intensity exercise practice and concurrent supplementation. Sustained exercise-induced oxidative stress as reflected in significantly increased blood thiobarbituric acid-reactive substances (TBARS) (+15%), protein carbonyl groups (PC) (+18%) and oxidized glutathione (GSSG) (+112%) concentrations, and leukocyte 8-OHdG contents (23%). Exercise decreased the reduced/oxidized glutathione (GSH/GSSG) molar ratio (-43%) and plasma vitamin C levels (-22%). Supplementation with Funciona™ was significant in preventing oxidative damage to lipid, protein and DNA, and normalizing blood GSSG, GSH/GSSG and vitamin C levels. Thus daily intake of the antioxidant functional beverage counteracts the exercise-induced oxidative stress in free-living older subjects, and might be necessary to restore impaired antioxidant balance due long-term regular exercise.
Maria E Muñoz; Ana I Galan; Encarna Palacios; Maria A Diez; Begoña Muguerza; Cesar Cobaleda; Jose I Calvo; Okezie I Aruoma; Isidro Sanchez-Garcia; Rafael Jimenez
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-10-24
Journal Detail:
Title:  Toxicology     Volume:  278     ISSN:  1879-3185     ISO Abbreviation:  Toxicology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  101-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Physiology & Pharmacology, Campus M. Unamuno, University of Salamanca, E-37007 Salamanca, Spain.
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MeSH Terms
Aged, 80 and over
Antioxidants / pharmacology*
Ascorbic Acid / blood
Cohort Studies
Dietary Supplements*
Eating / physiology
Glutathione / blood
Guanine / analogs & derivatives,  blood
Middle Aged
Oxidative Stress / drug effects*,  physiology
Physical Exertion / physiology*
Protein Carbonylation / physiology
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; 50-81-7/Ascorbic Acid; 6957-76-2/8-oxo-7,8-dihydrodeoxyguanine; 70-18-8/Glutathione; 73-40-5/Guanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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