| Effect of antihypertensive therapy using enalapril or losartan on haemostatic markers in essential hypertension: a pilot prospective randomised double-blind parallel group trial. | |
| | |
MedLine Citation:
|
PMID: 11376827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To test the hypothesis that the hypercoagulable state in hypertension is significantly altered by anti-hypertensive therapy, we conducted a pilot prospective randomised double-blind trial of 40 untreated hypertensive patients (30 males, mean age 59 years) who were treated with either enalapril (10-20 mg per day) or losartan (50-100 mg per day) for 8 weeks. Thrombogenicity was assessed by measurement of plasma fibrinogen, soluble P-selectin (an index of platelet activation), plasminogen activator inhibitor 1 (PAI-1, an index of fibrinolysis) and von Willebrand factor (an index of endothelial dysfunction). Baseline von Willebrand factor alone was significantly higher in untreated hypertensive patients compared to controls (P<0.001). Following 8 weeks treatment with enalapril (mean dose 17 mg/day) or losartan (mean dose 77 mg/day), there was a significant reduction in mean blood pressure from 169+/-11/94+/-8 mmHg (baseline) to 147+/-14/84+/-7 mmHg (post-treatment) (P<0.001). However, there were no statistically significant changes in the levels of haemostatic markers (von Willebrand factor, fibrinogen, s-Psel and PAI-1). Our pilot study confirms previous observations of endothelial dysfunction in hypertensives. However, plasma fibrinogen and indices of platelet activation, fibrinolysis or endothelial dysfunction were not significantly affected by antihypertensive treatment with enalapril or losartan, despite satisfactory blood pressure control. |
| | |
Authors:
|
F L Li-Saw-Hee; D G Beevers; G Y Lip |
Related Documents
:
|
10321447 - Effects of hypotensive and non-hypotensive doses of manidipine on structure, responses ... 11406907 - Antihypertensive efficacy and tolerability of low-dose perindopril/indapamide combinati... 15617457 - Clinical efficacy and safety of telmisartan 80 mg once daily vs. atenolol 50 mg once da... 18981627 - Effect of valsartan addition to amlodipine on insulin sensitivity in overweight-obese h... 9427067 - Pharmacological profile of jte-522, a novel prostaglandin h synthase-2 inhibitor, in rats. 2972667 - The multi-dose clinical tolerance and pharmacokinetics of the combined radiosensitizers... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of cardiology Volume: 78 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2001 May |
Date Detail:
|
Created Date: 2001-05-29 Completed Date: 2001-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 241-6 Citation Subset: IM |
Affiliation:
|
Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, B18 7QH, Birmingham, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin-Converting Enzyme Inhibitors
/
pharmacology* Biological Markers Cross-Sectional Studies Double-Blind Method Enalapril / pharmacology* Female Fibrinogen / metabolism Hemostasis / drug effects* Humans Hypertension / blood, drug therapy* Losartan / pharmacology* Male Middle Aged P-Selectin / blood Pilot Projects Plasminogen Inactivators / blood Prospective Studies Receptors, Angiotensin / antagonists & inhibitors* Statistics, Nonparametric von Willebrand Factor / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Biological Markers; 0/P-Selectin; 0/Plasminogen Inactivators; 0/Receptors, Angiotensin; 0/von Willebrand Factor; 114798-26-4/Losartan; 75847-73-3/Enalapril; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The prognostic significance of intermediate QRS prolongation in acute myocardial infarction.
Next Document: Comparison of the efficacy of a subcutaneous array electrode with a subcutaneous patch electrode, a ...