| Effect of antihypertensive drugs on neonatal blood pressure. | |
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MedLine Citation:
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PMID: 6518665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluates the perinatal outcome of infants born to ninety-five mothers with hypertension in pregnancy whose blood pressure was treated in a double blind trial comparing clonidine hydrochloride (C) and alpha-methyldopa (A). There were no fetal deaths and two neonatal deaths, giving a perinatal mortality of 2%. There was no significant difference between Groups C and A with regard to the gestation or weight at birth, incidence of intrauterine growth retardation, or condition at birth as judged by Apgar scores and acid-base status. No infant in either group developed significant hypotension or rebound hypertension. The blood pressure was not significantly different between Groups C and A, and controls. In each of these three groups there was a similar significant rise in systolic blood pressure with age. |
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Authors:
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D J Henderson-Smart; J S Horvath; A Phippard; A Korda; A Child; G G Duggin; B M Hall; B Storey; D J Tiller |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 11 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1984 Jul-Aug |
Date Detail:
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Created Date: 1985-03-07 Completed Date: 1985-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 351-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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pharmacology* Blood Pressure / drug effects* Clonidine / therapeutic use Female Humans Hypertension / drug therapy* Infant, Newborn Methyldopa / therapeutic use Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 4205-90-7/Clonidine; 555-30-6/Methyldopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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