Document Detail

Effect of antihypertensive drugs on neonatal blood pressure.
MedLine Citation:
PMID:  6518665     Owner:  NLM     Status:  MEDLINE    
This study evaluates the perinatal outcome of infants born to ninety-five mothers with hypertension in pregnancy whose blood pressure was treated in a double blind trial comparing clonidine hydrochloride (C) and alpha-methyldopa (A). There were no fetal deaths and two neonatal deaths, giving a perinatal mortality of 2%. There was no significant difference between Groups C and A with regard to the gestation or weight at birth, incidence of intrauterine growth retardation, or condition at birth as judged by Apgar scores and acid-base status. No infant in either group developed significant hypotension or rebound hypertension. The blood pressure was not significantly different between Groups C and A, and controls. In each of these three groups there was a similar significant rise in systolic blood pressure with age.
D J Henderson-Smart; J S Horvath; A Phippard; A Korda; A Child; G G Duggin; B M Hall; B Storey; D J Tiller
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  11     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1985-03-07     Completed Date:  1985-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  351-4     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Clonidine / therapeutic use
Hypertension / drug therapy*
Infant, Newborn
Methyldopa / therapeutic use
Pregnancy Complications, Cardiovascular / drug therapy*
Reg. No./Substance:
0/Antihypertensive Agents; 4205-90-7/Clonidine; 555-30-6/Methyldopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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