Document Detail


Effect of antiepileptic drugs on the cerebral amino acid uptake in vitro.
MedLine Citation:
PMID:  6120919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of four commonly used antiepileptic drugs (phenobarbital, diphenylhydantoin, clonazepam and dipropylacetate) on the uptake of amino acids were investigated in mouse cerebral slices. Phenobarbital and diphenylhydantoin showed a net influence on the transport of the neutral amino acids that are also precursors of monoamine neurotransmitters, increasing their uptake. A similar effect was observed for diphenylhydantoin on GABA uptake. The increase in phenylalanine and valine uptake induced by phenobarbital was at least partly due to a decreased release of these metabolites. No major effects were observed for clonazepam and dipropylacetate. Our findings seem to indicate that some antiepileptic drugs may influence cerebral transport of neurotransmitter substances; further investigations are needed to find out whether these effects play a role in the antiepileptic action of these drugs.
Authors:
M Saladini; M A Gabana; F Bracco; G Zanchin; F Maggioni; L Battistin
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Italian journal of neurological sciences     Volume:  2     ISSN:  0392-0461     ISO Abbreviation:  Ital J Neurol Sci     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006502     Medline TA:  Ital J Neurol Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  351-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption
Amino Acids / metabolism*
Animals
Anticonvulsants / pharmacology*
Brain / metabolism*
Clonazepam / pharmacology
Dose-Response Relationship, Drug
Male
Mice
Neurotransmitter Agents / metabolism
Phenobarbital / pharmacology
Phenytoin / pharmacology
Valproic Acid / pharmacology
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Anticonvulsants; 0/Neurotransmitter Agents; 1622-61-3/Clonazepam; 50-06-6/Phenobarbital; 57-41-0/Phenytoin; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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