| Effect of antiepileptic drugs on the cerebral amino acid uptake in vitro. | |
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MedLine Citation:
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PMID: 6120919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of four commonly used antiepileptic drugs (phenobarbital, diphenylhydantoin, clonazepam and dipropylacetate) on the uptake of amino acids were investigated in mouse cerebral slices. Phenobarbital and diphenylhydantoin showed a net influence on the transport of the neutral amino acids that are also precursors of monoamine neurotransmitters, increasing their uptake. A similar effect was observed for diphenylhydantoin on GABA uptake. The increase in phenylalanine and valine uptake induced by phenobarbital was at least partly due to a decreased release of these metabolites. No major effects were observed for clonazepam and dipropylacetate. Our findings seem to indicate that some antiepileptic drugs may influence cerebral transport of neurotransmitter substances; further investigations are needed to find out whether these effects play a role in the antiepileptic action of these drugs. |
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Authors:
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M Saladini; M A Gabana; F Bracco; G Zanchin; F Maggioni; L Battistin |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Italian journal of neurological sciences Volume: 2 ISSN: 0392-0461 ISO Abbreviation: Ital J Neurol Sci Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006502 Medline TA: Ital J Neurol Sci Country: ITALY |
Other Details:
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Languages: eng Pagination: 351-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Amino Acids / metabolism* Animals Anticonvulsants / pharmacology* Brain / metabolism* Clonazepam / pharmacology Dose-Response Relationship, Drug Male Mice Neurotransmitter Agents / metabolism Phenobarbital / pharmacology Phenytoin / pharmacology Valproic Acid / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Anticonvulsants; 0/Neurotransmitter Agents; 1622-61-3/Clonazepam; 50-06-6/Phenobarbital; 57-41-0/Phenytoin; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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