Document Detail


Effect of antidepressants on body weight, ethology and tumor growth of human pancreatic carcinoma xenografts in nude mice.
MedLine Citation:
PMID:  18666329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the effects of mirtazapine and fluoxetine, representatives of the noradrenergic and specific serotonergic antidepressant (NaSSA) and selective serotonin reuptake inhibitor (SSRI) antidepressant respectively, on body weight, ingestive behavior, locomotor activity and tumor growth of human pancreatic carcinoma xenografts in nude mice. METHODS: A subcutaneous xenograft model of human pancreatic cancer cell line SW1990 was established in nude mice. The tumor-bearing mice were randomly divided into mirtazapine group (10 mg/kg per day), fluoxetine group (10 mg/kg per day) and control group (an equivalent normal saline solution) (7 mice in each group). Doses of all drugs were administered orally, once a day for 42 d. Tumor volume and body weight were measured biweekly. Food intake was recorded once a week. Locomotor activity was detected weekly using an open field test (OFT). RESULTS: Compared to the fluoxetine, mirtazapine significantly increased food intake from d 14 to 42 and attenuated the rate of weight loss from d 28 to 42 (t = 4.38, P < 0.05). Compared to the control group, food intake was significantly suppressed from d 21 to 42 and weight loss was promoted from d 35 to 42 in the fluoxetine group (t = 2.52, P < 0.05). There was a significant difference in body weight of the mice after removal of tumors among the three groups. The body weight of mice was the heaviest (13.66 +/- 1.55 g) in the mirtazapine group and the lightest (11.39 +/- 1.45 g) in the fluoxetine group (F( (2,12) ) = 11.43, P < 0.01). The behavioral test on d 7 showed that the horizontal and vertical activities were significantly increased in the mirtazapine group compared with the fluoxetine and control groups (F( (2,18) ) = 10.89, P < 0.01). These effects disappeared in the mirtazapine and fluoxetine groups during 2-6 wk. The grooming activity was higher in the mirtazapine group than in the fluoxetine group (10.1 +/- 2.1 vs 7.1 +/- 1.9 ) (t = 2.40, P < 0.05) in the second week. There was no significant difference in tumor volume and tumor weight of the three groups. CONCLUSION: Mirtazapine and fluoxetine have no effect on the growth of pancreatic tumor. However, mirtazapine can significantly increase food intake and improve nutrition compared with fluoxetine in a pancreatic cancer mouse model.
Authors:
Lin Jia; Yuan-Yuan Shang; Yu-Yuan Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  14     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-30     Completed Date:  2008-11-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4377-82     Citation Subset:  IM    
Affiliation:
Department of Digestive Diseases, Guangzhou Municipal First People's Hospital, Guangzhou Medical College, No. 1 Panfu Road, Guangzhou 510180, Guangdong Province, China. jialin@medmail.com.cn
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MeSH Terms
Descriptor/Qualifier:
Animals
Antidepressive Agents, Second-Generation / pharmacology*
Antidepressive Agents, Tricyclic / pharmacology*
Body Weight
Carcinoma / drug therapy*,  pathology*
Cell Line, Tumor
Female
Fluoxetine / pharmacology
Male
Mianserin / analogs & derivatives,  pharmacology
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Transplantation
Pancreatic Neoplasms / drug therapy*,  pathology*
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Antidepressive Agents, Tricyclic; 24219-97-4/Mianserin; 54910-89-3/Fluoxetine; 61337-67-5/mirtazapine
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