| Effect of antidepressant drugs on the in-vitro egg-penetrating ability of golden hamster epididymal spermatozoa. | |
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MedLine Citation:
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PMID: 6687737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tricyclic antidepressants appeared to be without effect, except for desipramine which significantly decreased whiplash motility after spermatozoa were added to eggs, and clomipramine which decreased motility and whiplash motility in epididymal sperm suspensions after pretreatment of males. Mianserin and viloxazine were also without effect, but nomifensine significantly decreased sperm motility and whiplash motility and inhibited egg penetration almost completely. After 3 h preincubation with 0.75 mmol nomifensine hydrogen maleate/l, 2/181 and 0/256 eggs were penetrated in two separate series of experiments. Control groups in these series gave medians of 90-100% penetration by 4.5-5.5 h after spermatozoa and eggs were mixed. Maleic acid had a similar effect (1/253 eggs penetrated) whilst nomifensine hydrochloride was inactive, suggesting that the effect was due to the maleate moiety of the original nomifensine hydrogen maleate salt used. |
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Authors:
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D M Stein; H Schnieden |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of reproduction and fertility Volume: 68 ISSN: 0022-4251 ISO Abbreviation: J. Reprod. Fertil. Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-06-23 Completed Date: 1983-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376367 Medline TA: J Reprod Fertil Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 227-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antidepressive Agents, Tricyclic / pharmacology* Clomipramine / pharmacology Cricetinae Desipramine / pharmacology Female Fertilization / drug effects* Fertilization in Vitro / drug effects* Male Maleates / pharmacology Mesocricetus Mianserin / pharmacology Nomifensine / pharmacology Sperm Motility / drug effects Sperm-Ovum Interactions / drug effects* Spermatozoa / drug effects Viloxazine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 0/Maleates; 110-16-7/maleic acid; 24219-97-4/Mianserin; 24526-64-5/Nomifensine; 303-49-1/Clomipramine; 46817-91-8/Viloxazine; 50-47-5/Desipramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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