Document Detail

Effect of an anticalculus dentifrice on lesion progression under pH cycling conditions in vitro.
MedLine Citation:
PMID:  2850868     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to examine a sodium fluoride anticalculus dentifrice product containing soluble pyrophosphate for its ability to promote remineralization and/or inhibit demineralization of dental enamel in a pH cycling model in vitro. Enamel crowns with windows were subjected to 14 days of alternating demineralization and remineralization periods at 37 degrees C. Teeth were immersed 5 min daily in one of the test dentifrice systems (1:3 slurry in deionized water) between the demineralization and remineralization cycles. Test dentifrices included (1) sodium fluoride (NaF; 1,100 ppm F)/silica abrasive (Crest) and (2) NaF (1,100 ppm F) with 3.3% soluble pyrophosphate/silica abrasive (Crest Tartar Control). Controls included a placebo dentifrice (silica abrasive) with no added fluoride and a group which received no treatment at all, i.e., demineralization/remineralization only. Overall, both of the NaF dentifrices were very effective in limiting in vitro caries progression and were not significantly different from each other. Inclusion of pyrophosphate in the NaF dentifrice did not affect the net outcome of the cycling demineralization/remineralization processes which is in agreement with recent clinical and in situ studies of these products.
J D Featherstone; M Shariati; S Brugler; J Fu; D J White
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Caries research     Volume:  22     ISSN:  0008-6568     ISO Abbreviation:  Caries Res.     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-06     Completed Date:  1989-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0103374     Medline TA:  Caries Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  D; IM    
Department of Oral Biology, Eastman Dental Center, Rochester, N.Y.
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MeSH Terms
Dental Calculus / prevention & control*
Dental Caries / prevention & control*
Dental Enamel / anatomy & histology,  drug effects
Dental Enamel Solubility / drug effects
Diphosphates / therapeutic use*
Hydrogen-Ion Concentration
Sodium Fluoride / therapeutic use*
Tooth Remineralization*
Reg. No./Substance:
0/Dentifrices; 0/Diphosphates; 7681-49-4/Sodium Fluoride; 7722-88-5/sodium pyrophosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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