Document Detail


Effect of antibiotics on the in vitro neutrophil chemotactic response.
MedLine Citation:
PMID:  970760     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymorphonuclear neutrophilic leukocyte chemotaxis was examined in vitro in the presence of the following antibiotics: tetracycline, chloramphenicol, erythromycin, gentamicin, methicillin, sulfadiazine, cephalothin, oxacillin, nafcillin and clindamycin. Results indicate that high concentrations (1 mg/ml) of tetracycline, nafcillin, erythromycin and sulfadiazine inhibited the chemotactic response of neutrophils. Tetracycline produced an inhibition at concentrations as low as 1mug/ml. A stimulation of the neutrophil chemotactic response was observed in the presence of chloramphenicol in all concentrations. The results are discussed with particular emphasis on the implications to host immunity.
Authors:
J A Majeski; M A McClellan; J W Alexander
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American surgeon     Volume:  42     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  785-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Humans
Neutrophils / physiology*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

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