Document Detail

Effect of antibiotics on the bacterial population of the rabbit caecum.
MedLine Citation:
PMID:  17498210     Owner:  NLM     Status:  MEDLINE    
The effect feeding antibiotics has on the bacterial population of the rabbit caecum was investigated. No changes in total volatile fatty acid production or total bacterial counts were observed compared with nonantibiotic treated controls. However, treatment with chlortetracycline resulted in an increase of propionate at the apparent cost of butyrate (P<0.05). Denaturing gradient gel electrophoresis analysis indicated that the two antibiotics that inhibit protein synthesis (chlortetracycline and tiamulin) exerted the most similar changes on the bacterial population structure, decreasing the diversity of the profiles. Sequence analysis of DNA from excised denaturing gradient gel electrophoresis bands was carried out. The majority of the sequences observed were most similar to bacterial sequences previously described in other gut environments, with 11% being most similar to those previously reported from the rabbit, and 95% of the sequences having 95% or greater identity to sequences already in GenBank.
Leticia Abecia; Manuel Fondevila; Joaquim Balcells; Joan E Edwards; C James Newbold; Neil R McEwan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-10
Journal Detail:
Title:  FEMS microbiology letters     Volume:  272     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-21     Completed Date:  2007-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  144-53     Citation Subset:  IM    
Departamento de Producción Animal y Ciencia de los Alimentos, Universidad de Zaragoza, Spain.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AM229555;  AM229556;  AM229557;  AM229558;  AM229559;  AM229560;  AM229561;  AM229562;  AM229563;  AM229564;  AM229565;  AM229566;  AM229567;  AM229568;  AM229569;  AM229570;  AM229571;  AM229572;  AM229573;  AM229574;  AM229575;  AM229576;  AM229577;  AM229578;  AM229579;  AM229580;  AM229581;  AM229582;  AM229583;  AM229584;  AM229585;  AM229586;  AM229587;  AM229588;  AM229589;  AM229590;  AM229591;  AM229592;  AM229593;  AM229594;  AM229595;  AM229596;  AM229597;  AM229598;  AM229599;  AM229600;  AM229601;  AM229602;  AM229603;  AM229604;  AM229605;  AM229606;  AM229607;  AM229608;  AM229609;  AM229610;  AM229611;  AM229612;  AM229613;  AM229614;  AM229615;  AM229616;  AM229617;  AM229618;  AM229619;  AM229620;  AM229621;  AM229622;  AM229623;  AM229624;  AM229625;  AM229626;  AM229627;  AM229628;  AM229629;  AM229630;  AM229631;  AM229632;  AM229633;  AM229634;  AM229635;  AM229636;  AM229637;  AM229638;  AM229639;  AM229640;  AM229641;  AM229642;  AM229643;  AM229644;  AM229645;  AM229646;  AM229647;  AM229648;  AM229649;  AM229650;  AM229651;  AM229652;  AM229653;  AM229654
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Bacteria / classification,  drug effects*,  isolation & purification
Butyrates / analysis
Cecum / microbiology*
Colony Count, Microbial
DNA, Bacterial / analysis,  genetics
Electrophoresis, Polyacrylamide Gel
Fatty Acids, Volatile / biosynthesis
Feces / chemistry,  microbiology
Models, Animal
Molecular Sequence Data
Nucleic Acid Denaturation
Polymerase Chain Reaction
Propionic Acids / analysis
Sequence Analysis, DNA
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Butyrates; 0/DNA, Bacterial; 0/Fatty Acids, Volatile; 0/Propionic Acids; 79-09-4/propionic acid

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