| Effect of antibiotic and fluid resuscitation upon survival time in experimental intestinal ischemia. | |
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MedLine Citation:
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PMID: 3400026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute massive intestinal ischemia is an abdominal catastrophe. Prompt diagnosis and restoration of blood flow is essential; otherwise, massive intestinal resection occurs, leading to death or, in the survivors, intestinal cripples. In this study, the time of warm reversible ischemia in the canine intestine was explored. After this time was established, fluids and antibiotics were administered to note change in survival times. Massive intestinal ischemia (superior mesenteric artery was clamped) was tolerated without death for five hours (20 dogs in each group). With six hours of ischemia, a 10 per cent mortality rate occurred; with seven hours of ischemia, a 90 per cent mortality rate occurred. These dogs had a maintenance of 75 milliliters of fluid administered per hour. Using this group of dogs as the control (that is, the group with seven hour clamping time of the superior mesenteric artery with maintenance intravenously administered replacement), fluids were given to dogs in the experimental group to keep the pulmonary artery wedge pressure at a normal value (average of 300 milliliters per hour). This group of dogs had an increased survival rate of 40 per cent (ten dogs). Antibiotics were given to the dogs in the experimental group both before and after clamping, increasing the over-all survival rate to more than 80 per cent (46 dogs). Aggressive fluid replacement and antibiotic coverage may lengthen the so-called golden period in which intestinal ischemia may be reversed by revascularization. |
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Authors:
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W G Jamieson; G Pliagus; S Marchuk; G DeRose; D Moffat; L Stafford; R J Finley; W Sibbald; B M Taylor; J Duff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Surgery, gynecology & obstetrics Volume: 167 ISSN: 0039-6087 ISO Abbreviation: Surg Gynecol Obstet Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-02 Completed Date: 1988-09-02 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0101370 Medline TA: Surg Gynecol Obstet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 103-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Western Ontario, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / therapeutic use* Cefamandole / analogs & derivatives, therapeutic use Dogs Fluid Therapy* Intestines / blood supply* Ischemia / drug therapy, physiopathology, therapy* Pulmonary Wedge Pressure |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 34444-01-4/Cefamandole; 57268-80-1/cefamandole nafate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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