Document Detail


Effect of antiandrogen cyproterone acetate on the development of the antler cycle in Southern pudu (Pudu puda).
MedLine Citation:
PMID:  11857473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antler cycle of pudu is similar to other cervids, but unlike most boreal deer, male Southern pudu (Pudu puda) exhibits two seasonal peaks of LH and testosterone. In that respect, pudu is similar to roe deer. Whereas the antler cycle in some deer species, such as roe deer or white-tailed deer, is very sensitive to variation of testosterone, in other cervids, such as fallow deer or reindeer, a blockade of androgens with cyproterone acetate (CA) has little or no effect on the timing of the antler casting. In order to test the sensitivity of pudu antlers to variations of androgens, CA (administered 2x weekly at 50 mg/buck) was injected intramuscularly for 3 weeks in 5 adult male pudu, starting February 19 (late summer). Four other males of similar age served as controls. The experiment was performed at the University of Concepcion, Chile, latitude 36.6 degreeS. Blood samples were taken once a week between January 19 and April 3. In CA-treated bucks, the antlers were cast approximately 3 weeks after the initiation of CA treatment and a new antler growth began almost immediately. The antlers reached about 5 cm in length, before ceasing to grow at the end of April, when they became mineralized and were subsequently polished. CA had no effect on the already declining levels of LH. Plasma levels of testosterone in controls increased from February 15, whereas in CA-treated bucks remained depresses until March 21. It is concluded that similarly to white-tailed deer, the antler cycle of Southern pudu is very sensitive to manipulation of androgen levels.
Authors:
George A Bubenik; Eugenia Reyes; Dieter Schams; Alejandro Lobos; Ludek Bartos; Fernando Koerner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental zoology     Volume:  292     ISSN:  0022-104X     ISO Abbreviation:  J. Exp. Zool.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375365     Medline TA:  J Exp Zool     Country:  United States    
Other Details:
Languages:  eng     Pagination:  393-401     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Affiliation:
Department of Zoology, University of Guelph, Guelph, Ontario, Canada. gbubenik@uoguelph.ca
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MeSH Terms
Descriptor/Qualifier:
Androgen Antagonists / administration & dosage,  pharmacology*
Animals
Antlers / growth & development*
Cyproterone Acetate / administration & dosage,  pharmacology*
Deer / physiology*
Injections, Intramuscular
Luteinizing Hormone / blood
Male
Seasons
Testosterone / blood
Chemical
Reg. No./Substance:
0/Androgen Antagonists; 427-51-0/Cyproterone Acetate; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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