Document Detail


Effect of anti-epileptic drugs in pregnancy and teratogenesis.
MedLine Citation:
PMID:  23105768     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Epilepsy raises special concern in women during pregnancy. Antiepileptic drugs are known to induce major and minor malformations in the foetus. Aim of the study was to find an association between maternal serum alpha fetoprotein levels, foetal abnormalities and antiepileptic drugs mediated teratogenicity. Maternal serum alpha feto protein levels, kidney and liver function tests in age matched normal pregnant women and seizure free epileptic pregnant women during 12-14 weeks of gestation were estimated. Cases were subjected to ultrasonography at 11(th)-14(th) week of pregnancy and again at 20(th) week of pregnancy. maternal serum alfa feto protein was assayed by a specific Electro Chemiluminescence Immuno Assay test. There was no significant difference in kidney and liver function tests in cases as compared to controls. There were elevated levels of alpha feto protein in cases as compared to controls but this was not statistically significant. No anomalies were detected in ultrasound reports. Most women had normal full term delivery with healthy children but of low birth weight. No correlation was seen between maternal serum alfa feto protein levels and antiepileptic drug leading to teratogenesis.
Authors:
Sowbhagya Lakshmi; Kulkarni Sunanda
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Publication Detail:
Type:  Journal Article     Date:  2008-10-01
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  23     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2012-10-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Bangalore Medical College, Bangalore, 560 002 India.
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