| Effect of anti-alpha1-fetoprotein on alpha1-fetoprotein-producing rat tumors in vivo and in vitro. | |
| | |
MedLine Citation:
|
PMID: 56992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Active or passive immunization of rats to alpha1-fetoprotein (AFP) does not consistently inhibit the growth of AFP-producing transplantable hepatomas in vivo, and anti-AFP does not kill these hepatomas in vitro. However, 3 of 14 rats in 1 experiment responded to passive immunization by reversal of tumor growth as evidenced by normalization of elevated AFP serum concentrations, and 1 of 9 rats actively immunized with rat AFP in complete Freund's adjuvant had suppressed growth of transplantable hepatoma 7777. |
| | |
Authors:
|
S Sell; H W Sheppard; R Nickel; D Stillman; M Michaelsen |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cancer research Volume: 36 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1976 Feb |
Date Detail:
|
Created Date: 1976-07-06 Completed Date: 1976-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 476-80 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibodies, Anti-Idiotypic* Carcinoma, Hepatocellular / immunology* Cytotoxicity Tests, Immunologic Fetal Proteins / immunology* Hypersensitivity, Delayed Immunity, Active Immunity, Maternally-Acquired Immunization Liver Neoplasms Male Neoplasms, Experimental / immunology* Rats Skin Tests alpha-Fetoproteins / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Anti-Idiotypic; 0/Fetal Proteins; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Production of antisera with specificity for malignant melanoma and human fetal skin.
Next Document: Isolation and characterization of an antigen of the bovine C-type virus.