Document Detail

Effect of anteroventral third ventricle lesions on vascular sodium-pump activity in two-kidney Goldblatt hypertension.
MedLine Citation:
PMID:  6298107     Owner:  NLM     Status:  MEDLINE    
We studied the effects of anteroventral third ventricle (AV3V) lesions on the vascular Na+-pump activity and blood pressure of rats prepared by the two-kidney Goldblatt procedure. Blood pressures and Na+-pump activity of the isolated tail arteries, measured as ouabain-sensitive 86Rb+-uptake were determined in rats with renal artery clips, rats with AV3V lesions, and rats with AV3V lesions. Rats with renal artery clips developed higher blood pressures (40%) and higher vascular Na+-pump activity (20%-35%) than rats with no renal clips. Placement of AV3V lesions prior to the placement of renal clips prevented the increase in blood pressure and the increase in vascular Na+-pump activity. Plasma potassium and creatinine concentrations, nonspecific 86Rb+-uptake, and hematocrit were not different among these groups. Plasma sodium concentration was elevated in the AV3V lesioned control group. These experiments suggest a possible role of this CNS region in the regulation of vascular Na+-pump function during hypertensive states.
E Songu-Mize; S L Bealer; R W Caldwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  5     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1983 Mar-Apr
Date Detail:
Created Date:  1983-04-21     Completed Date:  1983-04-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I89-93     Citation Subset:  IM    
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MeSH Terms
Arteries / metabolism*
Blood Pressure
Cerebral Ventricles / physiology*
Hypertension, Renal / physiopathology*
Ion Channels / metabolism*
Rats, Inbred Strains
Rubidium / metabolism
Sodium / metabolism*
Tail / blood supply
Grant Support
Reg. No./Substance:
0/Ion Channels; 0/Radioisotopes; 7440-17-7/Rubidium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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