Document Detail

Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty.
MedLine Citation:
PMID:  19304090     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate irregularity of the anterior and posterior cornea before and after Descemet-stripping endothelial keratoplasty (DSEK) and its effect on visual acuity. SETTING: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. METHODS: Corneal data were acquired using a rotating Scheimpflug camera before and 1 month and 3 months after DSEK. Anterior and posterior corneal elevation data were decomposed into a set of Zernike polynomials up to the 8th order within a 4.0 mm diameter region. Total higher-order root mean square (HO-RMS) and RMS from the 3rd to 8th order were calculated. The effects of anterior and posterior surface irregularity on visual acuity were evaluated. RESULTS: This clinical study comprised 13 consecutive eyes of 12 bullous keratopathy patients. The mean best corrected visual acuity (BCVA) was 1.11 logMAR +/- 0.5 (SD) preoperatively, 0.49 +/- 0.49 logMAR 1 month postoperatively, and 0.27 +/- 0.32 logMAR at 3 months. The HO-RMS of the anterior surface 1 month (P = .040) and 3 months (P = .048) postoperatively was significantly lower than preoperatively. There were no significant differences in posterior surface HO-RMS between preoperatively and 1 month (P = .45) and 3 months (P = .054). The postoperative BCVA was significantly correlated with HO-RMS (P<.001), but not with posterior surface HO-RMS, at 3 months (P = .354). CONCLUSION: Postoperative BCVA correlated with irregularity of the anterior surface but not the posterior surface. In addition to corneal transparency, regularity of the anterior surface is an important factor in visual acuity after DSEK.
Takefumi Yamaguchi; Kazuno Negishi; Kazuko Yamaguchi; Dogru Murat; Yuichi Uchino; Shigeto Shimmura; Kazuo Tsubota
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  35     ISSN:  1873-4502     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  688-94     Citation Subset:  IM    
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Anterior Eye Segment / pathology*
Cell Transplantation / methods*
Corneal Diseases / surgery
Corneal Topography
Corneal Transplantation*
Descemet Membrane / surgery*
Endothelium, Corneal / transplantation*
Epithelium, Corneal / pathology*
Middle Aged
Vision, Ocular / physiology*
Visual Acuity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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