Document Detail


Effect of antepartum glucocorticoid administration upon neonatal respiratory distress syndrome and perinatal infection.
MedLine Citation:
PMID:  6691394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A double-blind, randomized study comparing the antepartum use of betamethasone (12 mg), methylprednisolone (125 mg), and hydrocortisone (250 mg) was performed to evaluate effect on neonatal respiratory distress syndrome and perinatal infection. Of 144 mothers and 149 infants entered, 92 mothers and 97 infants were available for analysis. The betamethasone-treated group had a significantly reduced incidence of severe respiratory distress syndrome (4%) compared with the control group (26%; p = 0.038); this effect was confined to patients who received at least two doses. No similar effect was found in the methylprednisolone or hydrocortisone groups. Neonatal infection and neonatal mortality rate were not affected by glucocorticoid use. Maternal infection was significantly increased in hydrocortisone-treated patients who were delivered vaginally compared with control patients (all patients: 50% versus 9.5%, p less than 0.05; with ruptured membranes: 63% versus 15%, p = 0.04). No similar increase in maternal infection was found with betamethasone or methylprednisolone use.
Authors:
P L Schmidt; M E Sims; H T Strassner; R H Paul; E Mueller; D McCart
Related Documents :
7518424 - Neonatal coxsackievirus group b infections: experience of a single department of neonat...
11394754 - Acute necrotizing bacterial tonsillitis with clostridium perfringens.
20732944 - High incidence of invasive group b streptococcal infections in hiv-exposed uninfected i...
7552594 - Ureaplasma urealyticum as a cause of pneumonia in preterm infants: analysis of the whit...
8579654 - Tracheal tdx fetal lung maturity test for assessing lung maturity in newborns with resp...
21660904 - A right-to-left or bidirectional ductal shunt in preterm neonates: grave implication?
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  148     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-02-23     Completed Date:  1984-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-86     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Apgar Score
Bacterial Infections / prevention & control*
Betamethasone / administration & dosage,  adverse effects
Birth Weight
Female
Fetal Membranes, Premature Rupture / drug therapy*
Glucocorticoids / administration & dosage*,  adverse effects
Humans
Hydrocortisone / administration & dosage,  adverse effects
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases / prevention & control*
Methylprednisolone / administration & dosage
Obstetric Labor, Premature / prevention & control
Pregnancy
Pregnancy Complications, Infectious / chemically induced
Respiratory Distress Syndrome, Newborn / prevention & control*
Risk
Chemical
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone; 50-23-7/Hydrocortisone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiovascular alterations in severe pregnancy-induced hypertension: acute effects of intravenous ma...
Next Document:  Significant fetal bradycardia during antepartum heart rate testing.