Document Detail

Effect of antepartum glucocorticoid administration upon neonatal respiratory distress syndrome and perinatal infection.
MedLine Citation:
PMID:  6691394     Owner:  NLM     Status:  MEDLINE    
A double-blind, randomized study comparing the antepartum use of betamethasone (12 mg), methylprednisolone (125 mg), and hydrocortisone (250 mg) was performed to evaluate effect on neonatal respiratory distress syndrome and perinatal infection. Of 144 mothers and 149 infants entered, 92 mothers and 97 infants were available for analysis. The betamethasone-treated group had a significantly reduced incidence of severe respiratory distress syndrome (4%) compared with the control group (26%; p = 0.038); this effect was confined to patients who received at least two doses. No similar effect was found in the methylprednisolone or hydrocortisone groups. Neonatal infection and neonatal mortality rate were not affected by glucocorticoid use. Maternal infection was significantly increased in hydrocortisone-treated patients who were delivered vaginally compared with control patients (all patients: 50% versus 9.5%, p less than 0.05; with ruptured membranes: 63% versus 15%, p = 0.04). No similar increase in maternal infection was found with betamethasone or methylprednisolone use.
P L Schmidt; M E Sims; H T Strassner; R H Paul; E Mueller; D McCart
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  148     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-02-23     Completed Date:  1984-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-86     Citation Subset:  AIM; IM    
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MeSH Terms
Apgar Score
Bacterial Infections / prevention & control*
Betamethasone / administration & dosage,  adverse effects
Birth Weight
Fetal Membranes, Premature Rupture / drug therapy*
Glucocorticoids / administration & dosage*,  adverse effects
Hydrocortisone / administration & dosage,  adverse effects
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases / prevention & control*
Methylprednisolone / administration & dosage
Obstetric Labor, Premature / prevention & control
Pregnancy Complications, Infectious / chemically induced
Respiratory Distress Syndrome, Newborn / prevention & control*
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone; 50-23-7/Hydrocortisone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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