Document Detail

Effect of antenatal dexamethasone administration on the prevention of respiratory distress syndrome.
MedLine Citation:
PMID:  7025638     Owner:  NLM     Status:  MEDLINE    
A double-blind, collaborative, randomized trial was initiated in 1976 to evaluate dexamethasone administered to mothers as a method of preventing neonatal respiratory distress syndrome (RDS). Five centers enrolled 696 women at risk for premature delivery. Up to 20 mg of dexamethasone phosphate (5 mg every 12 hours) or a placebo was administered intramuscularly. The overall incidence of RDS was different between control subjects (18.0%) and steroid-treating mothers (12.6%) (P less than 0.05). The effect was, however, mainly attributable to discernible differences among singleton female infants (P less than 0.001), whereas no treatment effect was observed in male infants (P = 0.96). Non-Caucasians were improved whereas Caucasians showed little benefit. Fetal and neonatal mortality and maternal postpartum infection rates were not different. Neurologic examination at 40 weeks' gestation demonstrated no significant difference in the rate of abnormal outcomes in the neonatal steroid group (P = 0.2).
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  141     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  276-87     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Continental Population Groups
Dexamethasone / analogs & derivatives*,  blood,  therapeutic use
Double-Blind Method
Fetal Membranes, Premature Rupture / complications
Infant, Newborn
Pre-Eclampsia / complications
Pregnancy, Multiple
Random Allocation
Respiratory Distress Syndrome, Newborn / prevention & control*
Sex Factors
United States
Grant Support
2949//PHS HHS; 2950//PHS HHS; N01-HR-6-2948/HR/NHLBI NIH HHS
Reg. No./Substance:
312-93-6/dexamethasone 21-phosphate; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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