Document Detail


Effect of antenatal corticosteroids on postmortem brain weight of preterm babies.
MedLine Citation:
PMID:  11408100     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the effects of single and repeated courses of antenatal corticosteroids on brain growth in very preterm babies. DESIGN: Retrospective study of 110 very preterm babies delivered at a single University Teaching Hospital between 1992 and 1999 who had a full necropsy including detailed examination of the brain. RESULTS: Mean brain weight did not differ significantly between babies who received corticosteroids and those who did not 160 vs. 157 g, (p=0.82), nor was there a difference between mean brain weight of stillborn or liveborn babies in relation to steroid use 164 vs. 159 g, (p=0.84) and 156 vs. 152g (p=0.81). There was no apparent dose-response relationship between the total number of doses of corticosteroids or timing since the first dose of corticosteroids and brain weight, p=0.95 and p=0.87. CONCLUSIONS: Single and multiple courses of antenatal corticosteroids had no significant effect on brain growth in babies delivered preterm who died but long-term follow-up studies are required to evaluate the functional neurological outcome of surviving children.
Authors:
D J Murphy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  63     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-15     Completed Date:  2001-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  113-22     Citation Subset:  IM    
Affiliation:
Division of Obstetrics and Gynaecology, University of Bristol, St. Michael's Hospital, Southwell St., Bristol BS2 8EG, UK. d.j.murphy@bristol.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced*
Adult
Brain / abnormalities,  drug effects*
Dexamethasone / administration & dosage,  adverse effects*
Dose-Response Relationship, Drug
Female
Glucocorticoids / administration & dosage,  adverse effects*
Hospitals, University
Humans
Infant, Newborn
Infant, Premature*
Injections, Intramuscular
Maternal Exposure*
Organ Size / drug effects*
Pregnancy
Prenatal Exposure Delayed Effects
Retrospective Studies
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone

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