Document Detail

Effect of antenatal administration of Betamethasone on hospital costs and survival of premature infants.
MedLine Citation:
PMID:  7312465     Owner:  NLM     Status:  MEDLINE    
Prenatal administration of glucocorticoids has been shown to decrease in incidence and severity of respiratory distress syndrome in premature infants, but little is known regarding the immediate economic impact of this reduction in respiratory morbidity. This study retrospectively examined 342 infants born during 1978 and 1979 and hospitalized in the University of Minnesota Hospitals. Comparison of survival and the hospital charges for infants whose mothers had not received prenatal glucocorticoid therapy showed that administration of glucocorticoids has a significant effect in lowering mortality in infants with birth weights between 750 and 1,249 gm (27 to 29 weeks' gestation). Glucocorticoid therapy was also effective in decreasing morbidity as reflected by hospital charges of surviving infants with birth weights between 1,250 and 1,749 gm (30 to 32 weeks' gestation). In both steroid-treated and nontreated mothers, prolongation of gestation decreases hospital charges in a linear fashion. The noted decrease in hospital costs should not justify prenatal glucocorticoid administration but should stimulate examination of long-term effects of the drug on surviving infants.
D E Johnson; D P Munson; T R Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  68     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  633-7     Citation Subset:  AIM; IM    
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MeSH Terms
Betamethasone / administration & dosage,  analogs & derivatives*
Birth Weight / drug effects
Costs and Cost Analysis
Gestational Age
Infant Mortality
Infant, Newborn
Infant, Premature*
Prenatal Care* / economics
Retrospective Studies
Sex Factors
Reg. No./Substance:
378-44-9/Betamethasone; 52081-45-5/betamethasone acetate phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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