Document Detail

Effect of antagonists for NK(2)and B(2) receptors on antigen-induced airway responses in allergic rabbits.
MedLine Citation:
PMID:  10718986     Owner:  NLM     Status:  MEDLINE    
The effects of the tachykinin NK(2)receptor antagonist, MEN 11420 (300 nmol/kg) and the bradykinin B(2)receptor antagonist, CP 0597 (17.2 and 172 nmol/kg) were studied in a rabbit model of antigen-induced airway responses. Antigen inhalation induced acute bronchoconstriction, airway hyperresponsiveness to histamine, and pulmonary eosinophil infiltration in 3-month-old rabbits immunized with Alternaria tenuis antigen within 24 h of birth. Treatment with MEN 11420 significantly reduced the acute bronchoconstriction induced by antigen, in terms of lung resistance. Antigen-induced changes in dynamic compliance were unaffected. CP 0597 had no effect on antigen-induced changes in lung function. Neither MEN 11420 nor CP 0597 had a significant effect on the antigen-induced increase in airway responsiveness to inhaled histamine or the pulmonary eosinophil infiltration 24 h after antigen challenge. We conclude that blockade of the NK(2)receptor can alter acute airway responses to antigen, but not antigen-induced eosinophilia or hyperresponsiveness to histamine. We also conclude that bradykinin B(2)receptor-mediated responses do not play a role in airway responses to antigen.
F E Woisin; T Matsumoto; G J Douglas; W Paul; E T Whalley; C P Page
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  13     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2000  
Date Detail:
Created Date:  2000-05-03     Completed Date:  2000-05-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  13-23     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Sackler Institute of Pulmonary Pharmacology, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, Guy's Campus, London, SE1 9RT, UK.
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MeSH Terms
Administration, Inhalation
Airway Resistance / drug effects*
Asthma / prevention & control*
Bronchial Hyperreactivity / physiopathology,  prevention & control
Bronchial Provocation Tests
Bronchoalveolar Lavage
Bronchodilator Agents / administration & dosage,  pharmacology*
Disease Models, Animal
Intradermal Tests
Oligopeptides / administration & dosage,  pharmacology*
Peptides, Cyclic / administration & dosage,  pharmacology*
Receptors, Bradykinin / antagonists & inhibitors*
Receptors, Tachykinin / antagonists & inhibitors*
Reg. No./Substance:
0/Bronchodilator Agents; 0/CP 0597; 0/MEN 11420; 0/Oligopeptides; 0/Peptides, Cyclic; 0/Receptors, Bradykinin; 0/Receptors, Tachykinin

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