Document Detail


Effect of anisodine on acute forebrain ischemia-reperfusion damage in rats.
MedLine Citation:
PMID:  9772669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To study the protective effect of anisodine (Ani) on acute forebrain ischemia-reperfusion injury in rats. METHODS: Both vertebral arteries were occluded by electrocautery. Severe, but transient bilateral cerebral ischemia was produced by clamping both common carotid arteries in rats. Atomic absorption spectrophotometric and spectrophotometric methods were used to determine the contents of calcium and extravasated Evans blue (EB), respectively, remained in forebrain at 60-min recirculation after 30-min ischemia. RESULTS: At 60-min recirculation, the brain calcium contents were increased from 112 +/- 6 micrograms/g brain dry weight in control (sham operation) group to 165 +/- 7 micrograms/g brain dry weight with marked increase of EB extravasation. Ani (2.5 mg.kg-1, i.p.), and scopolamine (Sco, 0.25 mg.kg-1, i.p.) decreased the elevated calcium and extravasated EB contents. CONCLUSION: Ani prevented the brain from ischemia insults through reducing intracellular calcium accumulation resulted from ischemia and reperfusion.
Authors:
W Xu; Y F Deng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhongguo yao li xue bao = Acta pharmacologica Sinica     Volume:  17     ISSN:  0253-9756     ISO Abbreviation:  Zhongguo Yao Li Xue Bao     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1998-11-06     Completed Date:  1998-11-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100330     Medline TA:  Zhongguo Yao Li Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  161-3     Citation Subset:  IM    
Affiliation:
Guangdong Medical College, Zhanjiang, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood-Brain Barrier / drug effects
Calcium / metabolism*
Calcium Channel Blockers / pharmacology*
Ischemic Attack, Transient / metabolism*
Prosencephalon / blood supply
Random Allocation
Rats
Rats, Sprague-Dawley
Reperfusion Injury / metabolism*
Scopolamine Derivatives / pharmacology*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Scopolamine Derivatives; 52646-92-1/anisodine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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