| Effect of anisodine on acute forebrain ischemia-reperfusion damage in rats. | |
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MedLine Citation:
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PMID: 9772669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study the protective effect of anisodine (Ani) on acute forebrain ischemia-reperfusion injury in rats. METHODS: Both vertebral arteries were occluded by electrocautery. Severe, but transient bilateral cerebral ischemia was produced by clamping both common carotid arteries in rats. Atomic absorption spectrophotometric and spectrophotometric methods were used to determine the contents of calcium and extravasated Evans blue (EB), respectively, remained in forebrain at 60-min recirculation after 30-min ischemia. RESULTS: At 60-min recirculation, the brain calcium contents were increased from 112 +/- 6 micrograms/g brain dry weight in control (sham operation) group to 165 +/- 7 micrograms/g brain dry weight with marked increase of EB extravasation. Ani (2.5 mg.kg-1, i.p.), and scopolamine (Sco, 0.25 mg.kg-1, i.p.) decreased the elevated calcium and extravasated EB contents. CONCLUSION: Ani prevented the brain from ischemia insults through reducing intracellular calcium accumulation resulted from ischemia and reperfusion. |
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Authors:
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W Xu; Y F Deng |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zhongguo yao li xue bao = Acta pharmacologica Sinica Volume: 17 ISSN: 0253-9756 ISO Abbreviation: Zhongguo Yao Li Xue Bao Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1998-11-06 Completed Date: 1998-11-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100330 Medline TA: Zhongguo Yao Li Xue Bao Country: CHINA |
Other Details:
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Languages: eng Pagination: 161-3 Citation Subset: IM |
Affiliation:
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Guangdong Medical College, Zhanjiang, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / drug effects Calcium / metabolism* Calcium Channel Blockers / pharmacology* Ischemic Attack, Transient / metabolism* Prosencephalon / blood supply Random Allocation Rats Rats, Sprague-Dawley Reperfusion Injury / metabolism* Scopolamine Derivatives / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Scopolamine Derivatives; 52646-92-1/anisodine; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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