Document Detail

Effect of an angiotensin-converting enzyme inhibitor on blood pressure and erythropoiesis in rats.
MedLine Citation:
PMID:  2143478     Owner:  NLM     Status:  MEDLINE    
Positive correlation between systolic blood pressure and plasma renin substrate was demonstrated in Wistar-Kyoto rats when plasma renin substrate was reduced to within a range of 18 and 88% of control values with varying amounts of ramipril. When ramipril was given in amounts that had a maximum effect on systolic blood pressure, marked changes in erythropoietin, reticulocyte count and hematocrit % were observed. Consistent blood pressure-lowering effect was evident for several weeks after ramipril withdrawal. Furthermore, blood pressure obtained 3 days after the rats were taken off ramipril correlated positively with the hematocrit % measured while the rats were still on ramipril (r = 0.83; P less than 0.001). Mean blood volume of 17 rats receiving ramipril was similar to that of the 10 control rats. Plasma and renal renin substrate were highly and positively correlated (r = 0.86; P less than 0.001). Inasmuch as plasma renin substrate is rate-limiting for angiotensin I, it may reflect intrarenal AII and prove to be a useful clinical assessment of converting enzyme inhibition. The increased levels of renin, renin substrate and packed cell volume seen in rats fed Purina basal diet (10% fat) as compared with rats fed Purina lab chow (4.5% fat), support the working hypothesis that intrarenal angiotensin II controls both blood pressure and erythropoiesis.
A B Gould; S A Goodman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  181     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-18     Completed Date:  1990-09-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  225-34     Citation Subset:  IM    
Department of Medicine, Hahnemann University, Philadelphia, PA 19102.
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MeSH Terms
Angiotensin II / pharmacology
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Bicyclo Compounds / pharmacology
Blood Pressure / drug effects*
Blood Volume / drug effects
Erythrocyte Count
Erythropoiesis / drug effects*
Erythropoietin / blood
Rats, Inbred WKY
Renin / blood
Reticulocytes / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Bicyclo Compounds; 11096-26-7/Erythropoietin; 11128-99-7/Angiotensin II; 87333-19-5/Ramipril; EC

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