Document Detail

Effect of angiotensin converting enzyme inhibition on blood pressure and renal function during open heart surgery.
MedLine Citation:
PMID:  2404429     Owner:  NLM     Status:  MEDLINE    
Activation of the renin-angiotensin system during open heart surgery may have consequences both beneficial in sustaining blood pressure and deleterious in compromising renal hemodynamics. The influence of short-term pretreatment with captopril on blood pressure and renal function was assessed double-blind versus placebo in 18 patients without pre-existing cardiac or renal failure, and undergoing coronary artery bypass. No difference in blood pressure and fluid requirement during the surgical period was observed between groups receiving captopril or placebo. Effective renal plasma flow and glomerular filtration rate decreased in the placebo group whereas they remained unaltered in the captopril group; during cardiopulmonary bypass, urinary excretion of sodium was greater in patients receiving captopril than those receiving placebo. These results suggest that captopril pretreatment does not compromise the control of blood pressure and renal function during open heart surgery; additional studies on the protective value of angiotensin-converting enzyme inhibitors are warranted in patients at higher risk for developing renal failure.
P Colson; J Ribstein; A Mimran; D Grolleau; P A Chaptal; B Roquefeuil
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesiology     Volume:  72     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-21     Completed Date:  1990-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  AIM; IM    
Department of Anesthesiology, Centre Hospitalier Universitaire, Montpellier, France.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Blood Pressure / drug effects*
Captopril / pharmacology
Coronary Artery Bypass*
Double-Blind Method
Glomerular Filtration Rate / drug effects
Kidney / drug effects*,  physiology
Middle Aged
Natriuresis / drug effects
Randomized Controlled Trials as Topic
Renal Circulation / drug effects
Renin / blood
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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