| Effect of the angiotensin II receptor blocker candesartan on fibrinolysis in patients with mild hypertension. | |
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MedLine Citation:
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PMID: 14686964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Impaired fibrinolysis is frequently observed in patients with the metabolic syndrome. Aim of the study was to examine the short-term effect of angiotensin II receptor blockade on the fibrinolytic system. METHODS: Seventy-four patients with mild hypertension were randomly assigned to a 7-day treatment period with either 16 mg candesartan cilexetil or placebo. Several variables of the fibrinolytic system such as plasminogen activator inhibitor-1 (PAI-1) antigen and activity, tissue plasminogen activator (t-PA) antigen and activity as well as circulating t-PA/PAI-1 complexes were determined. RESULTS: At baseline, the body mass index but not blood pressure was positively associated with PAI-1 antigen (r=0.314, p<0.01) and PAI-1 activity (r=0.425, p<0.01) but negatively with t-PA activity (r=-0.187, p < 0.05). A 7-day treatment with 16 mg candesartan cilexetil resulted in a significant greater reduction of diastolic blood pressure (-10.3 +/- 10.8 mmHg vs.-5.8 +/- 8.5 mmHg, p=0.03). However, there was no significant effect of candesartan on all parameters of the fibrinolytic system under investigation, i.e. circulating PAI-1 antigen, PAI-1 activity, t-PA antigen, t-PA activity and t-PA/PAI-1 complexes. Furthermore, candesartan did not affect the characteristic circadian pattern of the variables of the fibrinolytic system. CONCLUSION: We conclude that short-term blockade of the angiotensin II receptor subtype 1 with candesartan does not have an impact on fibrinolysis in patients with mild hypertension. |
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Authors:
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T Skurk; Y-M Lee; T-O Nicuta-Rölfs; B Haastert; A Wirth; H Hauner |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: 6 ISSN: 1462-8902 ISO Abbreviation: Diabetes Obes Metab Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-22 Completed Date: 2004-05-24 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: England |
Other Details:
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Languages: eng Pagination: 56-62 Citation Subset: IM |
Affiliation:
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German Diabetes Research Institute at the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anthropometry Antihypertensive Agents / pharmacology* Benzimidazoles / pharmacology* Biphenyl Compounds / pharmacology* Circadian Rhythm / drug effects Double-Blind Method Female Fibrinolysis / drug effects* Humans Hypertension / blood*, drug therapy Male Middle Aged Plasminogen Activator Inhibitor 1 / blood Receptors, Angiotensin / antagonists & inhibitors* Tetrazoles* Tissue Plasminogen Activator / blood |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Benzimidazoles; 0/Biphenyl Compounds; 0/Plasminogen Activator Inhibitor 1; 0/Receptors, Angiotensin; 0/Tetrazoles; 145040-37-5/candesartan cilexetil; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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