| Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone. | |
| | |
MedLine Citation:
|
PMID: 8013547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In dispersed rabbit adrenocortical glomerulosa cells, a non-peptide angiotensin II (AT1) receptor antagonist, CV-11974 (10(-10)-10(-5) M), competitively inhibited angiotensin II- or angiotensin III-stimulated aldosterone production, whereas PD123177, an angiotensin AT2 receptor antagonist, did not. CV-11974 inhibited aldosterone production induced by 4 mM K+ but not by 12 mM K+. CV-11974 had no effect on adrenocorticotropic hormone-stimulated aldosterone or corticosterone production, but inhibited angiotensin II-stimulated corticosterone production. In the rat, TCV-116, the prodrug of CV-11974, (0.1 and 1 mg/kg, p.o.) markedly reduced the elevation of both plasma aldosterone concentration and blood pressure induced by i.v. infusion of angiotensin II. In spontaneously hypertensive rats, TCV-116 at daily p.o. doses of 0.1, 1 and 10 mg/kg for 2 weeks caused a dose-dependent reduction of blood pressure and plasma aldosterone concentration without affecting plasma corticosterone. Thus, TCV-116 inhibited the induction of aldosterone production by not only exogenous but also endogenous angiotensin II. |
| | |
Authors:
|
T Wada; Y Inada; T Sanada; M Ojima; Y Shibouta; M Noda; K Nishikawa |
Related Documents
:
|
8733007 - Mineralocorticoids, salt, hypertension: effects on the heart. 18268147 - Association of leukocyte telomere length with circulating biomarkers of the renin-angio... 7037337 - A case of normoreninemic, normotensive primary aldosteronism associated with essential ... 9768657 - Rapid cardiovascular action of aldosterone in man. 2379947 - Physiological, psychological, and behavioral factors and white coat hypertension. 991407 - Echocardiographic evaluation of the valsalva maneuver in healthy subjects and patients ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of pharmacology Volume: 253 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1994 Feb |
Date Detail:
|
Created Date: 1994-07-26 Completed Date: 1994-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 27-34 Citation Subset: IM |
Affiliation:
|
Pharmaceutical Research Laboratories I, Takeda Chemical Industries, Ltd., Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adrenocorticotropic Hormone / pharmacology Aldosterone / biosynthesis*, blood Angiotensin II / administration & dosage, pharmacology Angiotensin III / administration & dosage, pharmacology Animals Benzimidazoles / administration & dosage, pharmacology* Biphenyl Compounds / administration & dosage, pharmacology* Cells, Cultured Corticosterone / biosynthesis Hypertension / metabolism, physiopathology Imidazoles / administration & dosage, pharmacology Infusions, Intravenous Male Pyridines / administration & dosage, pharmacology Rabbits Rats Rats, Inbred SHR Rats, Wistar Receptors, Angiotensin / antagonists & inhibitors* Tetrazoles / administration & dosage, pharmacology* Zona Glomerulosa / cytology, drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Benzimidazoles; 0/Biphenyl Compounds; 0/Imidazoles; 0/Pyridines; 0/Receptors, Angiotensin; 0/Tetrazoles; 11128-99-7/Angiotensin II; 114785-12-5/PD 123177; 12687-51-3/Angiotensin III; 139481-59-7/candesartan; 145040-37-5/candesartan cilexetil; 50-22-6/Corticosterone; 52-39-1/Aldosterone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intrahippocampal administration of a glycine site antagonist impairs working memory performance of r...
Next Document: Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation i...