| Effect of anger provocation on endothelium-dependent and -independent vasodilation. | |
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MedLine Citation:
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PMID: 17350383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anger is an independent predictor of coronary heart disease events, although the mechanisms for this relation are unclear. The effects of an anger-provoking interview compared with a neutral interview on endothelium-dependent and -independent vasodilation assessed by brachial artery ultrasound were examined in 14 healthy subjects without coronary heart disease risk factors. The anger provocation condition, but not the neutral condition, caused a significant impairment in endothelium-dependent vasodilation at 90 minutes compared with baseline (p = 0.004) and 30 minutes (p = 0.013). Similarly, endothelium-independent vasodilation was significantly impaired at 90 minutes after the angry interview compared with baseline (p = 0.003) and 30 minutes (p = 0.001). The decreases in endothelium-dependent and -independent vasodilation were greater after the anger-provoking interview than after the neutral interview, especially between 30 and 90 minutes. In conclusion, preliminary results suggest that an episode of anger is associated with a dysregulation in endothelium-dependent and -independent pathways, suggesting that these mechanisms might contribute to the link between anger and coronary heart disease events. |
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Authors:
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Daichi Shimbo; William Chaplin; Oluwaseun Akinola; Adam Harris; Dennis Abraham; Shunichi Homma; William Gerin |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2007-01-26 |
Journal Detail:
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Title: The American journal of cardiology Volume: 99 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-04-26 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 860-3 Citation Subset: AIM; IM |
Affiliation:
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Behavioral Cardiovascular Health and Hypertension Program, Division of General Medicine, Columbia University Medical Center, New York, New York, USA. ds2231@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anger* Brachial Artery / physiopathology*, ultrasonography Endothelium, Vascular / physiopathology, ultrasonography Female Humans Interviews as Topic Male Middle Aged Myocardial Infarction / physiopathology, ultrasonography Nitroglycerin / diagnostic use Treatment Outcome Vasodilation Vasodilator Agents / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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HL072866/HL/NHLBI NIH HHS; HL076857/HL/NHLBI NIH HHS; K23 HL072866-04/HL/NHLBI NIH HHS; M01 RR000645/RR/NCRR NIH HHS; RR00645/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 55-63-0/Nitroglycerin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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