Document Detail


Effect of anger provocation on endothelium-dependent and -independent vasodilation.
MedLine Citation:
PMID:  17350383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anger is an independent predictor of coronary heart disease events, although the mechanisms for this relation are unclear. The effects of an anger-provoking interview compared with a neutral interview on endothelium-dependent and -independent vasodilation assessed by brachial artery ultrasound were examined in 14 healthy subjects without coronary heart disease risk factors. The anger provocation condition, but not the neutral condition, caused a significant impairment in endothelium-dependent vasodilation at 90 minutes compared with baseline (p = 0.004) and 30 minutes (p = 0.013). Similarly, endothelium-independent vasodilation was significantly impaired at 90 minutes after the angry interview compared with baseline (p = 0.003) and 30 minutes (p = 0.001). The decreases in endothelium-dependent and -independent vasodilation were greater after the anger-provoking interview than after the neutral interview, especially between 30 and 90 minutes. In conclusion, preliminary results suggest that an episode of anger is associated with a dysregulation in endothelium-dependent and -independent pathways, suggesting that these mechanisms might contribute to the link between anger and coronary heart disease events.
Authors:
Daichi Shimbo; William Chaplin; Oluwaseun Akinola; Adam Harris; Dennis Abraham; Shunichi Homma; William Gerin
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2007-01-26
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-04-26     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  860-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anger*
Brachial Artery / physiopathology*,  ultrasonography
Endothelium, Vascular / physiopathology,  ultrasonography
Female
Humans
Interviews as Topic
Male
Middle Aged
Myocardial Infarction / physiopathology,  ultrasonography
Nitroglycerin / diagnostic use
Treatment Outcome
Vasodilation
Vasodilator Agents / diagnostic use
Grant Support
ID/Acronym/Agency:
HL072866/HL/NHLBI NIH HHS; HL076857/HL/NHLBI NIH HHS; K23 HL072866/HL/NHLBI NIH HHS; M01 RR000645/RR/NCRR NIH HHS; RR00645/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Vasodilator Agents; G59M7S0WS3/Nitroglycerin
Comments/Corrections

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