| Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats. | |
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MedLine Citation:
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PMID: 21246710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Microbubble contrast agents are currently implemented in a variety of both clinical and preclinical ultrasound imaging studies. The therapeutic and diagnostic capabilities of these contrast agents are limited by their short in-vivo lifetimes, and research to lengthen their circulation times is on going. In this manuscript, observations are presented from a controlled experiment performed to evaluate differences in circulation times for lipid shelled perfluorocarbon-filled contrast agents circulating within rodents as a function of inhaled anesthesia carrier gas. METHODS: The effects of two common anesthesia carrier gas selections - pure oxygen and medical air were observed within five rats. Contrast agent persistence within the kidney was measured and compared for oxygen and air anesthesia carrier gas for six bolus contrast injections in each animal. Simulations were performed to examine microbubble behavior with changes in external environment gases. RESULTS: A statistically significant extension of contrast circulation time was observed for animals breathing medical air compared to breathing pure oxygen. Simulations support experimental observations and indicate that enhanced contrast persistence may be explained by reduced ventilation/perfusion mismatch and classical diffusion, in which nitrogen plays a key role by contributing to the volume and diluting other gas species in the microbubble gas core. CONCLUSION: Using medical air in place of oxygen as the carrier gas for isoflurane anesthesia can increase the circulation lifetime of ultrasound microbubble contrast agents. |
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Authors:
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Lee Mullin; Ryan Gessner; James Kwan; Mehmet Kaya; Mark A Borden; Paul A Dayton |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-19 |
Journal Detail:
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Title: Contrast media & molecular imaging Volume: 6 ISSN: 1555-4317 ISO Abbreviation: Contrast Media Mol Imaging Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-06-23 Completed Date: 2011-11-02 Revised Date: 2012-05-04 |
Medline Journal Info:
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Nlm Unique ID: 101286760 Medline TA: Contrast Media Mol Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 126-31 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC 27599, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Anesthetics, Inhalation* Animals Contrast Media / chemistry, pharmacokinetics* Diagnostic Imaging / methods Fluorocarbons Gases / pharmacology* Lipids Microbubbles* Rats Ultrasonography / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB009066-03/EB/NIBIB NIH HHS; R01 EB009066-04/EB/NIBIB NIH HHS; R01EB009066/EB/NIBIB NIH HHS; R21 EB005325-04/EB/NIBIB NIH HHS; R21 EB005325-05/EB/NIBIB NIH HHS; R21EB005325/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Contrast Media; 0/Fluorocarbons; 0/Gases; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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