| Effect of amlodipine in human internal mammary artery and clinical implications. | |
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MedLine Citation:
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PMID: 21095344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Graft spasm remains challenging in CABG (coronary artery bypass grafting) surgery. We investigated the inhibitory effect of a dihydropyridine calcium antagonist amlodipine on the vasoconstriction mediated by potassium chloride (KCl), human urotensin-II (hU-II), and U46619 in human internal mammary artery (IMA) from patients undergoing CABG. METHODS: Isolated IMA rings (n = 78, taken from 42 patients) were studied in organ baths in two ways: the relaxing effect of amlodipine on vasoconstrictor-induced precontraction by KCl, hU-II, and U46619 and the depressing effect of amlodipine on the contraction. RESULTS: Amlodipine caused full relaxation in KCl-contracted (98.0% ± 2.1%), in hU-II-contracted (98.5% ± 2.4%), and in U46619-contracted (96.3% ± 1.3%) IMA rings (n = 8) with 15.5-fold higher potency to KCl than to hU-II (effective concentration causing 50% of maximal response [EC(50)]: -8.17 ± 0.28 vs -6.98 ± 0.01 log M, p < 0.001) and 19.5-fold that to U46619 (EC(50): -8.17 ± 0.28 vs -6.88 ± 0.08 log M, p < 0.001). Pretreatment of IMA with plasma concentrations of amlodipine (-6.6 log M) significantly depressed subsequent contraction to KCl (from 20.8 ± 2.5 mN to 7.6 ± 3.0 mN, p = 0.004) and hU-II (from 14.1 ± 4.2 mN to 3.8 ± 2.0 mN, p = 0.026), but did not significantly affect the contraction to U46619. CONCLUSIONS: We conclude that in human IMA amlodipine has a potent inhibitory effect on the vasoconstriction mediated by a variety of vasoconstrictors. Thus, use of amlodipine in CABG patients is favored in treating and preventing graft spasm. |
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Authors:
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Xiao-Yan Bai; Xiao-Cheng Liu; Wen-Bin Jing; Qin Yang; Xiang-Dong Tang; Guo-Wei He |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 90 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1952-7 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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TEDA International Cardiovascular Hospital, Medical College, Nankai University, Tianjin, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
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pharmacology Amlodipine / pharmacology* Calcium Channel Blockers / pharmacology* Humans Mammary Arteries / cytology, drug effects*, physiology Muscle, Smooth, Vascular / drug effects, physiology Potassium Chloride / pharmacology Urotensins / pharmacology Vasoconstrictor Agents / pharmacology Vasodilation / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Urotensins; 0/Vasoconstrictor Agents; 7447-40-7/Potassium Chloride; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 88150-42-9/Amlodipine; 9047-55-6/urotensin II |
| Comments/Corrections | |
Comment In:
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Ann Thorac Surg. 2010 Dec;90(6):1957-8
[PMID:
21095345
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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