Document Detail

Effect of amlodipine in human internal mammary artery and clinical implications.
MedLine Citation:
PMID:  21095344     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Graft spasm remains challenging in CABG (coronary artery bypass grafting) surgery. We investigated the inhibitory effect of a dihydropyridine calcium antagonist amlodipine on the vasoconstriction mediated by potassium chloride (KCl), human urotensin-II (hU-II), and U46619 in human internal mammary artery (IMA) from patients undergoing CABG.
METHODS: Isolated IMA rings (n = 78, taken from 42 patients) were studied in organ baths in two ways: the relaxing effect of amlodipine on vasoconstrictor-induced precontraction by KCl, hU-II, and U46619 and the depressing effect of amlodipine on the contraction.
RESULTS: Amlodipine caused full relaxation in KCl-contracted (98.0% ± 2.1%), in hU-II-contracted (98.5% ± 2.4%), and in U46619-contracted (96.3% ± 1.3%) IMA rings (n = 8) with 15.5-fold higher potency to KCl than to hU-II (effective concentration causing 50% of maximal response [EC(50)]: -8.17 ± 0.28 vs -6.98 ± 0.01 log M, p < 0.001) and 19.5-fold that to U46619 (EC(50): -8.17 ± 0.28 vs -6.88 ± 0.08 log M, p < 0.001). Pretreatment of IMA with plasma concentrations of amlodipine (-6.6 log M) significantly depressed subsequent contraction to KCl (from 20.8 ± 2.5 mN to 7.6 ± 3.0 mN, p = 0.004) and hU-II (from 14.1 ± 4.2 mN to 3.8 ± 2.0 mN, p = 0.026), but did not significantly affect the contraction to U46619.
CONCLUSIONS: We conclude that in human IMA amlodipine has a potent inhibitory effect on the vasoconstriction mediated by a variety of vasoconstrictors. Thus, use of amlodipine in CABG patients is favored in treating and preventing graft spasm.
Xiao-Yan Bai; Xiao-Cheng Liu; Wen-Bin Jing; Qin Yang; Xiang-Dong Tang; Guo-Wei He
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  90     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1952-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
TEDA International Cardiovascular Hospital, Medical College, Nankai University, Tianjin, China.
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MeSH Terms
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology
Amlodipine / pharmacology*
Calcium Channel Blockers / pharmacology*
Mammary Arteries / cytology,  drug effects*,  physiology
Muscle, Smooth, Vascular / drug effects,  physiology
Potassium Chloride / pharmacology
Urotensins / pharmacology
Vasoconstrictor Agents / pharmacology
Vasodilation / drug effects,  physiology*
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Urotensins; 0/Vasoconstrictor Agents; 7447-40-7/Potassium Chloride; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 88150-42-9/Amlodipine; 9047-55-6/urotensin II
Comment In:
Ann Thorac Surg. 2010 Dec;90(6):1957-8   [PMID:  21095345 ]

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