Document Detail


Effect of amlodipine on cardiopulmonary performance in volunteers.
MedLine Citation:
PMID:  11153533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. In order to exclude a significant effect of the calcium channel antagonist amlodipine on cardiopulmonary performance in normal subjects, we performed a double-blind cross-over study of amlodipine (10 mg daily for 2 weeks) on oxygen uptake and catecholamine responses during exercise in eight volunteers. 2. Despite a therapeutic plasma concentration of amlodipine (22.8+/-9 ng/mL), there was no change in resting heart rate or blood pressure. Amlodipine did not cause significant change in oxygen uptake at the anaerobic threshold or at maximum exercise and there was also no change in heart rate or catecholamine responses. 3. Although there was an awareness of peripheral vasodilation and reports of lethargy during the active treatment period, the volunteers had no objective evidence of a decrease in cardiopulmonary performance. We suggest that use of amlodipine as a vasodilator in the perioperative period would not add to the myocardial depressant effects of general anaesthesia in patients with normal cardiac function.
Authors:
L Lay; A R Bjorksten; G V Stainsby; D W Blake
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  28     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-03-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amlodipine / pharmacology*
Analysis of Variance
Calcium Channel Blockers / pharmacology*
Catecholamines / metabolism
Cross-Over Studies
Double-Blind Method
Epinephrine / blood*
Exercise Test / drug effects
Heart Rate / drug effects*,  physiology
Humans
Middle Aged
Norepinephrine / blood*
Oxygen Consumption / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Catecholamines; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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