| Effect of amlodipine on cardiopulmonary performance in volunteers. | |
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MedLine Citation:
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PMID: 11153533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. In order to exclude a significant effect of the calcium channel antagonist amlodipine on cardiopulmonary performance in normal subjects, we performed a double-blind cross-over study of amlodipine (10 mg daily for 2 weeks) on oxygen uptake and catecholamine responses during exercise in eight volunteers. 2. Despite a therapeutic plasma concentration of amlodipine (22.8+/-9 ng/mL), there was no change in resting heart rate or blood pressure. Amlodipine did not cause significant change in oxygen uptake at the anaerobic threshold or at maximum exercise and there was also no change in heart rate or catecholamine responses. 3. Although there was an awareness of peripheral vasodilation and reports of lethargy during the active treatment period, the volunteers had no objective evidence of a decrease in cardiopulmonary performance. We suggest that use of amlodipine as a vasodilator in the perioperative period would not add to the myocardial depressant effects of general anaesthesia in patients with normal cardiac function. |
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Authors:
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L Lay; A R Bjorksten; G V Stainsby; D W Blake |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 28 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2001 Jan-Feb |
Date Detail:
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Created Date: 2001-01-10 Completed Date: 2001-03-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 25-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amlodipine / pharmacology* Analysis of Variance Calcium Channel Blockers / pharmacology* Catecholamines / metabolism Cross-Over Studies Double-Blind Method Epinephrine / blood* Exercise Test / drug effects Heart Rate / drug effects*, physiology Humans Middle Aged Norepinephrine / blood* Oxygen Consumption / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Catecholamines; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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