Document Detail


Effect of amitriptyline on neurotransmitter levels in adult mice following infection with the avirulent strain of Semliki Forest virus.
MedLine Citation:
PMID:  8099606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infection of adult mice with the avirulent strain of Semliki Forest virus (SFV) led to neurochemical abnormalities, notably depressed levels of catecholamines (CATs) such as noradrenaline (NA), adrenaline (A) and 3-methoxy-4-hydroxyphenylglycol (MHPG) (a metabolite of NA) particularly in the hypothalamus and the inferior colliculus but not in the temporal cortex. In addition, depressed levels of NA and A were also found in the cerebrospinal fluid (CSF) and the serum. Administration of a tricyclic antidepressant drug, amitriptyline, kept the levels of NA, A and MHPG similar to those of the saline-treated control mice in the hypothalamus, inferior colliculus and CSF.
Authors:
S Mehta; L M Parsons; H E Webb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  116     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-15     Completed Date:  1993-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  110-6     Citation Subset:  IM    
Affiliation:
Neurovirology Unit, Rayne Institute, United Medical and Dental School, Guy's Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Amitriptyline / pharmacology*
Animals
Brain / drug effects,  metabolism*
Chromatography, High Pressure Liquid
Epinephrine / blood,  cerebrospinal fluid,  metabolism
Female
Hypothalamus / drug effects,  metabolism
Inferior Colliculi / drug effects,  metabolism
Male
Methoxyhydroxyphenylglycol / metabolism
Mice
Neurotransmitter Agents / metabolism*
Norepinephrine / blood,  cerebrospinal fluid,  metabolism
Semliki forest virus*
Temporal Lobe / drug effects,  metabolism
Time Factors
Togaviridae Infections / metabolism*
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents; 50-48-6/Amitriptyline; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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