Document Detail

Effect of amitriptyline on neurotransmitter levels in adult mice following infection with the avirulent strain of Semliki Forest virus.
MedLine Citation:
PMID:  8099606     Owner:  NLM     Status:  MEDLINE    
Infection of adult mice with the avirulent strain of Semliki Forest virus (SFV) led to neurochemical abnormalities, notably depressed levels of catecholamines (CATs) such as noradrenaline (NA), adrenaline (A) and 3-methoxy-4-hydroxyphenylglycol (MHPG) (a metabolite of NA) particularly in the hypothalamus and the inferior colliculus but not in the temporal cortex. In addition, depressed levels of NA and A were also found in the cerebrospinal fluid (CSF) and the serum. Administration of a tricyclic antidepressant drug, amitriptyline, kept the levels of NA, A and MHPG similar to those of the saline-treated control mice in the hypothalamus, inferior colliculus and CSF.
S Mehta; L M Parsons; H E Webb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  116     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-15     Completed Date:  1993-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  110-6     Citation Subset:  IM    
Neurovirology Unit, Rayne Institute, United Medical and Dental School, Guy's Hospital, London, UK.
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MeSH Terms
Amitriptyline / pharmacology*
Brain / drug effects,  metabolism*
Chromatography, High Pressure Liquid
Epinephrine / blood,  cerebrospinal fluid,  metabolism
Hypothalamus / drug effects,  metabolism
Inferior Colliculi / drug effects,  metabolism
Methoxyhydroxyphenylglycol / metabolism
Neurotransmitter Agents / metabolism*
Norepinephrine / blood,  cerebrospinal fluid,  metabolism
Semliki forest virus*
Temporal Lobe / drug effects,  metabolism
Time Factors
Togaviridae Infections / metabolism*
Reg. No./Substance:
0/Neurotransmitter Agents; 50-48-6/Amitriptyline; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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