| Effect of amiodarone in the Wolff-Parkinson-White syndrome. A clinical and electrophysiological study. | |
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MedLine Citation:
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PMID: 367085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Six patients with Wolff-Parkinson-White (WPW) syndrome were given long-term treatment with amiodarone. Symptomatic relief was obtained in all. Tolerance to the drug was good. Reversible corneal changes appeared after some weeks' treatment in five patients. No thyroid side-effects were noticed. Prior to treatment, dual atrioventricular (AV) conduction was demonstrated on His bundle electrograms in all six patients. Recordings were made at varied heart rates, using atrial and ventricular pacing. Reciprocating tachycardia was readily provoked by properly timed extra stimuli in all patients. When amiodarone treatment had become clinically effective, a second comparative study was made in four patients after 26--85 days' treatment. Amiodarone reduced heart rate and second degree AV block appeared at a lower atrial pacing rate. It increased the refractory periods of right atrium, AV node, and the accessory pathway in proportion to the duration of treatment. Induction of tachycardia was effectively prevented by the drug. It appears that amiodarone in chronic treatment has a predictable and unique depressant action on cardiac conduction, supporting the opinion that this compound, despite side-effects, has an important role to play in the treatment of refractory arrhythmias in patients with the WPW syndrome. |
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Authors:
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V Rasmussen; J Berning |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Acta medica Scandinavica Volume: 205 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1979 |
Date Detail:
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Created Date: 1979-03-24 Completed Date: 1979-03-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amiodarone / administration & dosage, adverse effects, therapeutic use* Benzofurans / therapeutic use* Bundle of His / drug effects, physiopathology Cardiac Pacing, Artificial Clinical Trials as Topic Drug Evaluation Electrocardiography Female Heart Conduction System / drug effects*, physiopathology Heart Rate / drug effects Humans Male Middle Aged Sinoatrial Node / drug effects, physiopathology Time Factors Wolff-Parkinson-White Syndrome / drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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