Document Detail

Effect of amiodarone on the descending limb of the T wave.
MedLine Citation:
PMID:  12972125     Owner:  NLM     Status:  MEDLINE    
Comparing patients treated after myocardial infarction with amiodarone or with placebo, we found a significant rate-dependent prolongation of TpTe interval in patients who received amiodarone. Patients who had arrhythmic death had significantly longer TpTe intervals than others on placebo but not on amiodarone. Assuming that TpTe reflects transmural repolarization heterogeneity, our findings suggest that heterogeneity and arrhythmic risk are increased by amiodarone. This contradicts the finding of decreased transmural repolarization heterogeneity by amiodarone and the appreciated antiarrhythmic efficacy of this drug.
Peter Smetana; Esther Pueyo; Katerina Hnatkova; Velislav Batchvarov; A John Camm; Marek Malik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  92     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-15     Completed Date:  2003-12-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742-6     Citation Subset:  AIM; IM    
Department of Cardiological Sciences, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
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MeSH Terms
Amiodarone / administration & dosage,  adverse effects*,  therapeutic use*
Anti-Arrhythmia Agents / administration & dosage,  adverse effects*,  therapeutic use*
Dose-Response Relationship, Drug
Electrocardiography, Ambulatory
Heart Conduction System / drug effects,  physiopathology
Long QT Syndrome / chemically induced*,  mortality,  physiopathology*
Middle Aged
Myocardial Infarction / drug therapy*,  mortality,  physiopathology*
Randomized Controlled Trials as Topic
Retrospective Studies
Severity of Illness Index
Survival Rate
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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