Document Detail

Effect of aminophylline on plasma [K+] and hypoxic ventilatory response during mild exercise in men.
MedLine Citation:
PMID:  7836197     Owner:  NLM     Status:  MEDLINE    
To examine the role of endogenous adenosine on the hypoxic ventilatory response (HVR) enhanced during exercise, we measured HVR at rest and during mild exercise (12.5 W) in nine healthy men in a supine position after pretreatment with aminophylline (5 mg/kg), an adenosine receptor blocker, or dipyridamole (0.6 mg/kg), an adenosine uptake blocker, by using a 3-day double-blind placebo-controlled design. Although HVR was enhanced during exercise on all occasions, HVR with aminophylline [0.42 +/- 0.07 (SE) l.min-1.%fall-1 of arterial O2 saturation] was significantly lower than that with placebo (0.64 +/- 0.13 l.min-1.%fall-1) or dipyridamole (0.64 +/- 0.08 l.min-1.%fall-1) during exercise (P < 0.05 for both) at similar end-tidal PCO2 on the 3 days but not at rest. We then examined the changes in plasma K+ concentration ([K+]) and catecholamines, the other possible endogenous potentiators of the carotid body activity. The exercise- and hypoxia-induced increases in plasma [K+] were significantly lower with aminophylline (0.23 +/- 0.09 meq/l) than with the placebo (0.51 +/- 0.10 meq/l) or dypyridamole (0.58 +/- 0.13 meq/l) (P < 0.05 for both). We therefore conclude that aminophylline attenuates the enhancement of HVR during mild exercise and that this might be due to its attenuating effect on exercise- and hypoxia-associated increases in plasma [K+] rather than due to its antagonizing effect on endogenous adenosine.
T Igarashi; M Nishimura; Y Akiyama; M Yamamoto; K Miyamoto; Y Kawakami
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  77     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-24     Completed Date:  1995-02-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1763-8     Citation Subset:  IM; S    
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Aminophylline / pharmacology*
Anoxia / physiopathology
Catecholamines / blood
Chromatography, High Pressure Liquid
Dipyridamole / pharmacology
Double-Blind Method
Exercise / physiology*
Fluorescence Polarization Immunoassay
Infusions, Intravenous
Potassium / blood*
Respiration / drug effects*,  physiology
Reg. No./Substance:
0/Catecholamines; 317-34-0/Aminophylline; 58-32-2/Dipyridamole; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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